Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1923380..1924034 Replicon chromosome
Accession NZ_CP083512
Organism Escherichia coli strain elppa4

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag K9U07_RS09390 Protein ID WP_000244777.1
Coordinates 1923380..1923787 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A7B2N3K9
Locus tag K9U07_RS09395 Protein ID WP_001604807.1
Coordinates 1923768..1924034 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9U07_RS09370 (1919337) 1919337..1921070 - 1734 WP_000813188.1 single-stranded-DNA-specific exonuclease RecJ -
K9U07_RS09375 (1921076) 1921076..1921786 - 711 WP_000715210.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K9U07_RS09380 (1921811) 1921811..1922707 - 897 WP_000806650.1 site-specific tyrosine recombinase XerD -
K9U07_RS09385 (1922819) 1922819..1923340 + 522 WP_001055874.1 flavodoxin FldB -
K9U07_RS09390 (1923380) 1923380..1923787 - 408 WP_000244777.1 protein YgfX Toxin
K9U07_RS09395 (1923768) 1923768..1924034 - 267 WP_001604807.1 FAD assembly factor SdhE Antitoxin
K9U07_RS09400 (1924277) 1924277..1925257 + 981 WP_001604809.1 tRNA-modifying protein YgfZ -
K9U07_RS09405 (1925334) 1925334..1925993 - 660 WP_000250269.1 hemolysin III family protein -
K9U07_RS09410 (1926157) 1926157..1926468 - 312 WP_001604811.1 N(4)-acetylcytidine aminohydrolase -
K9U07_RS09415 (1926513) 1926513..1927946 + 1434 WP_001604813.1 6-phospho-beta-glucosidase BglA -
K9U07_RS09420 (1928008) 1928008..1928751 - 744 WP_001366570.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T216690 WP_000244777.1 NZ_CP083512:c1923787-1923380 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T216690 NZ_CP113216:c3928506-3928189 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGTCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10595.21 Da        Isoelectric Point: 5.6375

>AT216690 WP_001604807.1 NZ_CP083512:c1924034-1923768 [Escherichia coli]
MYINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT216690 NZ_CP113216:c3928196-3927909 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACGTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
AlphaFold DB A0A7B2N3K9

References