Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2489764..2490599 Replicon chromosome
Accession NZ_CP083503
Organism Escherichia coli strain elppa5

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1C0Y405
Locus tag K9U08_RS12385 Protein ID WP_001774607.1
Coordinates 2490222..2490599 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A1M2U6P5
Locus tag K9U08_RS12380 Protein ID WP_001774606.1
Coordinates 2489764..2490132 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9U08_RS12340 (2484796) 2484796..2485476 + 681 WP_032082725.1 WYL domain-containing protein -
K9U08_RS12345 (2485624) 2485624..2486301 + 678 WP_001097305.1 hypothetical protein -
K9U08_RS12350 (2486307) 2486307..2486540 + 234 WP_001278287.1 DUF905 family protein -
K9U08_RS12355 (2486639) 2486639..2487457 + 819 WP_016238867.1 DUF932 domain-containing protein -
K9U08_RS12360 (2487796) 2487796..2488275 + 480 WP_032152717.1 antirestriction protein -
K9U08_RS12365 (2488291) 2488291..2488767 + 477 WP_001297237.1 RadC family protein -
K9U08_RS12370 (2488830) 2488830..2489051 + 222 WP_000692312.1 DUF987 domain-containing protein -
K9U08_RS12375 (2489070) 2489070..2489714 + 645 WP_001774605.1 hypothetical protein -
K9U08_RS12380 (2489764) 2489764..2490132 + 369 WP_001774606.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
K9U08_RS12385 (2490222) 2490222..2490599 + 378 WP_001774607.1 TA system toxin CbtA family protein Toxin
K9U08_RS12390 (2490596) 2490596..2491084 + 489 WP_001774608.1 DUF5983 family protein -
K9U08_RS12395 (2491096) 2491096..2491293 + 198 WP_032152719.1 DUF957 domain-containing protein -
K9U08_RS12400 (2491378) 2491378..2492220 + 843 WP_032152755.1 DUF4942 domain-containing protein -
K9U08_RS12405 (2492562) 2492562..2492732 + 171 Protein_2433 IS110 family transposase -
K9U08_RS12410 (2493543) 2493543..2494526 + 984 WP_032152721.1 KpsF/GutQ family sugar-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14218.20 Da        Isoelectric Point: 7.8045

>T216657 WP_001774607.1 NZ_CP083503:2490222-2490599 [Escherichia coli]
MKTLPDTHVREASRCPPPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDTVNFLVEKYALIRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T216657 NZ_CP113201:163415-163897 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.31 Da        Isoelectric Point: 5.8746

>AT216657 WP_001774606.1 NZ_CP083503:2489764-2490132 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT216657 NZ_CP113201:163161-163427 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATTCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C0Y405

Antitoxin

Source ID Structure
AlphaFold DB A0A1M2U6P5

References