Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 2489764..2490599 | Replicon | chromosome |
Accession | NZ_CP083503 | ||
Organism | Escherichia coli strain elppa5 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | A0A1C0Y405 |
Locus tag | K9U08_RS12385 | Protein ID | WP_001774607.1 |
Coordinates | 2490222..2490599 (+) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | A0A1M2U6P5 |
Locus tag | K9U08_RS12380 | Protein ID | WP_001774606.1 |
Coordinates | 2489764..2490132 (+) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K9U08_RS12340 (2484796) | 2484796..2485476 | + | 681 | WP_032082725.1 | WYL domain-containing protein | - |
K9U08_RS12345 (2485624) | 2485624..2486301 | + | 678 | WP_001097305.1 | hypothetical protein | - |
K9U08_RS12350 (2486307) | 2486307..2486540 | + | 234 | WP_001278287.1 | DUF905 family protein | - |
K9U08_RS12355 (2486639) | 2486639..2487457 | + | 819 | WP_016238867.1 | DUF932 domain-containing protein | - |
K9U08_RS12360 (2487796) | 2487796..2488275 | + | 480 | WP_032152717.1 | antirestriction protein | - |
K9U08_RS12365 (2488291) | 2488291..2488767 | + | 477 | WP_001297237.1 | RadC family protein | - |
K9U08_RS12370 (2488830) | 2488830..2489051 | + | 222 | WP_000692312.1 | DUF987 domain-containing protein | - |
K9U08_RS12375 (2489070) | 2489070..2489714 | + | 645 | WP_001774605.1 | hypothetical protein | - |
K9U08_RS12380 (2489764) | 2489764..2490132 | + | 369 | WP_001774606.1 | type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA | Antitoxin |
K9U08_RS12385 (2490222) | 2490222..2490599 | + | 378 | WP_001774607.1 | TA system toxin CbtA family protein | Toxin |
K9U08_RS12390 (2490596) | 2490596..2491084 | + | 489 | WP_001774608.1 | DUF5983 family protein | - |
K9U08_RS12395 (2491096) | 2491096..2491293 | + | 198 | WP_032152719.1 | DUF957 domain-containing protein | - |
K9U08_RS12400 (2491378) | 2491378..2492220 | + | 843 | WP_032152755.1 | DUF4942 domain-containing protein | - |
K9U08_RS12405 (2492562) | 2492562..2492732 | + | 171 | Protein_2433 | IS110 family transposase | - |
K9U08_RS12410 (2493543) | 2493543..2494526 | + | 984 | WP_032152721.1 | KpsF/GutQ family sugar-phosphate isomerase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14218.20 Da Isoelectric Point: 7.8045
>T216657 WP_001774607.1 NZ_CP083503:2490222-2490599 [Escherichia coli]
MKTLPDTHVREASRCPPPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDTVNFLVEKYALIRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
MKTLPDTHVREASRCPPPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDTVNFLVEKYALIRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T216657 NZ_CP113201:163415-163897 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13593.31 Da Isoelectric Point: 5.8746
>AT216657 WP_001774606.1 NZ_CP083503:2489764-2490132 [Escherichia coli]
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
VSDTLSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT216657 NZ_CP113201:163161-163427 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATTCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATTCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1C0Y405 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1M2U6P5 |