Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3012935..3013589 Replicon chromosome
Accession NC_008258
Organism Shigella flexneri 5 str. 8401

Toxin (Protein)


Gene name cptA Uniprot ID Q0T101
Locus tag SFV_RS16335 Protein ID WP_000244767.1
Coordinates 3012935..3013342 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q0T100
Locus tag SFV_RS16340 Protein ID WP_000354044.1
Coordinates 3013323..3013589 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SFV_RS16315 3008892..3010625 - 1734 WP_000813187.1 single-stranded-DNA-specific exonuclease RecJ -
SFV_RS16320 3010631..3011341 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
SFV_RS16325 3011366..3012262 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
SFV_RS16330 3012374..3012895 + 522 WP_001055867.1 flavodoxin FldB -
SFV_RS16335 3012935..3013342 - 408 WP_000244767.1 protein YgfX Toxin
SFV_RS16340 3013323..3013589 - 267 WP_000354044.1 FAD assembly factor SdhE Antitoxin
SFV_RS16345 3013832..3014812 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
SFV_RS16350 3015008..3015667 - 660 WP_000250267.1 hemolysin III family protein -
SFV_RS16355 3015831..3016141 - 311 Protein_2986 ASCH domain-containing protein -
SFV_RS16360 3016186..3017618 + 1433 Protein_2987 6-phospho-beta-glucosidase BglA -
SFV_RS16365 3017675..3018418 - 744 Protein_2988 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15978.91 Da        Isoelectric Point: 10.9373

>T21665 WP_000244767.1 NC_008258:c3013342-3012935 [Shigella flexneri 5 str. 8401]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRCINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T21665 NC_008258:c3013342-3012935 [Shigella flexneri 5 str. 8401]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTATTTGATTGCG
TTCGCAGCCAGCGGTGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10529.09 Da        Isoelectric Point: 5.1599

>AT21665 WP_000354044.1 NC_008258:c3013589-3013323 [Shigella flexneri 5 str. 8401]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEIMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT21665 NC_008258:c3013589-3013323 [Shigella flexneri 5 str. 8401]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATAATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TIU0

Antitoxin

Source ID Structure
AlphaFold DB A0A4P7TIU2

References