Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 862579..863105 | Replicon | chromosome |
| Accession | NZ_CP083503 | ||
| Organism | Escherichia coli strain elppa5 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | K9U08_RS04375 | Protein ID | WP_000323025.1 |
| Coordinates | 862579..862866 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | K9U08_RS04380 | Protein ID | WP_000534858.1 |
| Coordinates | 862866..863105 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K9U08_RS04330 (857663) | 857663..858121 | - | 459 | WP_000526135.1 | IS200/IS605-like element IS200C family transposase | - |
| K9U08_RS04335 (858572) | 858572..858787 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| K9U08_RS04340 (859088) | 859088..859300 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| K9U08_RS04345 (859355) | 859355..859444 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| K9U08_RS04350 (859722) | 859722..860474 | - | 753 | WP_001047135.1 | antitermination protein | - |
| K9U08_RS04355 (860488) | 860488..861537 | - | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| K9U08_RS04360 (861539) | 861539..861817 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| K9U08_RS04365 (861884) | 861884..862135 | - | 252 | WP_000980994.1 | protein Rem | - |
| K9U08_RS04370 (862352) | 862352..862507 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| K9U08_RS04375 (862579) | 862579..862866 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| K9U08_RS04380 (862866) | 862866..863105 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| K9U08_RS04385 (863130) | 863130..863435 | + | 306 | WP_001326990.1 | protein YdfV | - |
| K9U08_RS04390 (863638) | 863638..863970 | + | 333 | WP_001301033.1 | FlxA-like family protein | - |
| K9U08_RS04395 (864407) | 864407..864556 | - | 150 | WP_011443592.1 | protein YdfW | - |
| K9U08_RS04400 (864629) | 864629..865699 | - | 1071 | Protein_869 | ISNCY family transposase | - |
| K9U08_RS04405 (866204) | 866204..867226 | - | 1023 | WP_000915483.1 | DUF4868 domain-containing protein | - |
| K9U08_RS04410 (867229) | 867229..867843 | - | 615 | WP_001265627.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 819834..881407 | 61573 | |
| - | flank | IS/Tn | - | - | 857663..858121 | 458 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T216644 WP_000323025.1 NZ_CP083503:c862866-862579 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T216644 NZ_CP113193:273475-273759 [Klebsiella pneumoniae]
ATGACCTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTCCATGGACGCAAAGACCAGTACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTAACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACAATTTGACCAAACACAGAAATTAA
ATGACCTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTCCATGGACGCAAAGACCAGTACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTAACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACAATTTGACCAAACACAGAAATTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT216644 WP_000534858.1 NZ_CP083503:c863105-862866 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT216644 NZ_CP113193:273237-273485 [Klebsiella pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGCACCTTCAATGCAGG
AGAAGGTGCCCCGGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGCTGGGTCATATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACCTATAA
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGCACCTTCAATGCAGG
AGAAGGTGCCCCGGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGCTGGGTCATATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|