Detailed information of TA system TA216611

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2375558..2376390
• Replicon: chromosome
• Accession: NZ_CP083497
• Organism: Escherichia coli strain elppa6

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A836ZBT7
• Locus tag: K9U09_RS11505
• Protein ID: WP_001598217.1
• Coordinates: 2375558..2375932 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: K9U09_RS11510
• Protein ID: WP_001598216.1
• Coordinates: 2376022..2376390 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9U09_RS11470 (2370913)	2370913..2371893	+	981	WP_049033570.1	sialate O-acetylesterase	-
K9U09_RS11475 (2371901)	2371901..2372005	-	105	Protein_2246	HNH endonuclease	-
K9U09_RS11480 (2372105)	2372105..2372977	+	873	WP_000168567.1	HNH endonuclease	-
K9U09_RS11485 (2373088)	2373088..2374086	-	999	WP_001240356.1	membrane protein	-
K9U09_RS11490 (2374627)	2374627..2374776	-	150	Protein_2249	hypothetical protein	-
K9U09_RS11495 (2374861)	2374861..2375058	-	198	WP_024192776.1	DUF957 domain-containing protein	-
K9U09_RS11500 (2375070)	2375070..2375561	-	492	WP_001598218.1	DUF5983 family protein	-
K9U09_RS11505 (2375558)	2375558..2375932	-	375	WP_001598217.1	TA system toxin CbtA family protein	Toxin
K9U09_RS11510 (2376022)	2376022..2376390	-	369	WP_001598216.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
K9U09_RS11515 (2376470)	2376470..2376692	-	223	Protein_2254	DUF987 domain-containing protein	-
K9U09_RS11520 (2376761)	2376761..2377237	-	477	WP_032198294.1	RadC family protein	-
K9U09_RS11525 (2377253)	2377253..2377738	-	486	WP_000206667.1	antirestriction protein	-
K9U09_RS11530 (2377830)	2377830..2378648	-	819	WP_001598214.1	DUF932 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimE / fimB	2365874..2409837	43963

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 13990.98 Da
• Isoelectric Point: 7.8045

>T216611 WP_001598217.1 NZ_CP083497:c2375932-2375558 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLGRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Nucleotide

• Length: 375 bp

>T216611 NZ_CP113179:c114171-113689 [Klebsiella pneumoniae]
ATGGGAATGAGAGCGCCTGAATCCCTGACGGCTGAACATAACATCGCTGAGTTCTGCTGCCAGGAGCCTGCCCTTAATGA
GTGGTTAAAGAAGAAGGCTCTCAGAAACCACAGTACCGGCATTTCCCGTGTCTATGTCGTCTGCGCAGAAAACACTAACC
GGGTCATCGGTTATTATTGTTTATCTTCGGGTAGCGTCCACCGTAACACAGTGCCTGGGGCCTATAGACGCAACGCGCCT
GATGTCATTCCAGTCATTGTTTTGGGACGGCTTGCCATCGACCAGGCCTGGGCCGGGAATGGGCTTGGTGCCGCACTTCT
TAAGGATGCTATATACCGTACGCAAAACATAGCCTTTCAGGTCGGGGTGAGAGCACTGGCCGTGCATGCGCTGAATGAAG
AAGTTAAATGTTTTTACACCCGTTTTGGCTTTGAGCCTTCCATAGTCAACACGCTGACATTGTTATTCCCGATAAAAGTC
TGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13605.40 Da
• Isoelectric Point: 7.3992

>AT216611 WP_001598216.1 NZ_CP083497:c2376390-2376022 [Escherichia coli]
VSDTLSGTTHPDDNNSHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLGSRGYVYMAVYPTPETKK

Nucleotide

• Length: 369 bp

>AT216611 NZ_CP113179:c114440-114162 [Klebsiella pneumoniae]
ATGAAACCAGACGTTCGTGAAGCTCCGATTAATATCCGGGCCAAAACATCACAGCGTGACCTGATCGACATGGCCGCAAG
CCTGGTCTCAAAATCACGGACTGATTTTATGCTTGAGGTTGCCTGCAGGGAGGCACAGGACATTCTGCTTGATCAACGCC
TGTTCCTCCTCAATGACAATCAGTTTGAGGCGTTTATTGAAGAGCTTGACGCCCCAATAACGCCGGAGCGCCAGGCGCGA
ATCGATAACCTGATGAACCGCAAATCACCATGGGAATGA

Structures

Toxin

• AlphaFold DB: A0A836ZBT7