Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-Phd |
| Location | 7664..8265 | Replicon | plasmid unnamed5 |
| Accession | NZ_CP083486 | ||
| Organism | Escherichia coli strain elppa9 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | U9YA20 |
| Locus tag | K9U12_RS25895 | Protein ID | WP_001216045.1 |
| Coordinates | 7664..8044 (-) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | U9YQH9 |
| Locus tag | K9U12_RS25900 | Protein ID | WP_001190712.1 |
| Coordinates | 8044..8265 (-) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K9U12_RS25870 (K9U12_25875) | 3104..4588 | - | 1485 | WP_000124150.1 | terminase | - |
| K9U12_RS25875 (K9U12_25880) | 4588..5781 | - | 1194 | WP_106489616.1 | terminase | - |
| K9U12_RS25880 (K9U12_25885) | 5868..6320 | - | 453 | WP_001326849.1 | late promoter-activating protein | - |
| K9U12_RS25885 (K9U12_25890) | 6409..7452 | - | 1044 | WP_106489615.1 | DUF968 domain-containing protein | - |
| K9U12_RS25890 (K9U12_25895) | 7480..7659 | - | 180 | WP_001339207.1 | hypothetical protein | - |
| K9U12_RS25895 (K9U12_25900) | 7664..8044 | - | 381 | WP_001216045.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| K9U12_RS25900 (K9U12_25905) | 8044..8265 | - | 222 | WP_001190712.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| K9U12_RS25905 (K9U12_25910) | 8338..8727 | - | 390 | WP_000506730.1 | S24 family peptidase | - |
| K9U12_RS25910 (K9U12_25915) | 8902..9486 | + | 585 | WP_044068914.1 | hypothetical protein | - |
| K9U12_RS25915 (K9U12_25920) | 9487..9849 | + | 363 | WP_228571361.1 | hypothetical protein | - |
| K9U12_RS25920 (K9U12_25925) | 9861..10100 | - | 240 | WP_023356286.1 | DNA polymerase III subunit theta | - |
| K9U12_RS25925 (K9U12_25930) | 10103..10369 | - | 267 | WP_000903204.1 | hypothetical protein | - |
| K9U12_RS25930 (K9U12_25935) | 10415..11188 | - | 774 | WP_223677252.1 | hypothetical protein | - |
| K9U12_RS25935 (K9U12_25940) | 11170..11544 | - | 375 | WP_032353387.1 | hypothetical protein | - |
| K9U12_RS25940 (K9U12_25945) | 11551..11844 | - | 294 | WP_000269001.1 | hypothetical protein | - |
| K9U12_RS25945 (K9U12_25950) | 12023..12256 | - | 234 | WP_000517421.1 | hypothetical protein | - |
| K9U12_RS26945 | 12339..13025 | - | 687 | WP_234287463.1 | DUF550 domain-containing protein | - |
| K9U12_RS26950 | 12999..13124 | - | 126 | Protein_21 | DUF550 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..94363 | 94363 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 13588.29 Da Isoelectric Point: 5.1514
>T216554 WP_001216045.1 NZ_CP083486:c8044-7664 [Escherichia coli]
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE
MRHISPEELIALHDANISRYGGLPGMSDPGRAEAIIGRVQARVAYEEITDLFEVSATYLVATARGHIFNDANKRTALNSA
LLFLRRNGVQVFDSPELADLTVGAATGEISVSSVADTLRRLYGSAE
Download Length: 381 bp
>T216554 NZ_CP113165:642533-642901 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGACAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGACAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
Antitoxin
Download Length: 74 a.a. Molecular weight: 8133.10 Da Isoelectric Point: 4.7708
>AT216554 WP_001190712.1 NZ_CP083486:c8265-8044 [Escherichia coli]
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
MQSINFRTARGNLSEVLNNVEAGEEVEITRRGREPAVIVSKATFEAYKKAALDAEFASLFDTLDSTNKELVNR
Download Length: 222 bp
>AT216554 NZ_CP113165:642315-642536 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CLP7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829CJB6 |