Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2818783..2819618 Replicon chromosome
Accession NZ_CP083481
Organism Escherichia coli strain elppa9

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0J1YPH7
Locus tag K9U12_RS13905 Protein ID WP_029701676.1
Coordinates 2819241..2819618 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0K5N986
Locus tag K9U12_RS13900 Protein ID WP_021553056.1
Coordinates 2818783..2819151 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9U12_RS13865 (2814445) 2814445..2815125 + 681 WP_029702103.1 WYL domain-containing protein -
K9U12_RS13870 (2815273) 2815273..2815950 + 678 WP_001097302.1 hypothetical protein -
K9U12_RS13875 (2815956) 2815956..2816189 + 234 WP_001278293.1 DUF905 family protein -
K9U12_RS13880 (2816279) 2816279..2817097 + 819 WP_001175165.1 DUF932 domain-containing protein -
K9U12_RS13885 (2817363) 2817363..2817842 + 480 WP_001564060.1 antirestriction protein -
K9U12_RS13890 (2817858) 2817858..2818334 + 477 WP_021553055.1 RadC family protein -
K9U12_RS13895 (2818399) 2818399..2818620 + 222 WP_000692345.1 DUF987 domain-containing protein -
K9U12_RS13900 (2818783) 2818783..2819151 + 369 WP_021553056.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
K9U12_RS13905 (2819241) 2819241..2819618 + 378 WP_029701676.1 TA system toxin CbtA family protein Toxin
K9U12_RS13910 (2819615) 2819615..2819764 + 150 Protein_2726 DUF5983 family protein -
K9U12_RS13915 (2819843) 2819843..2820037 + 195 WP_024181941.1 DUF957 domain-containing protein -
K9U12_RS13920 (2820122) 2820122..2820964 + 843 WP_022645115.1 DUF4942 domain-containing protein -
K9U12_RS13925 (2821713) 2821713..2823251 + 1539 WP_001187196.1 lysine decarboxylation/transport transcriptional activator CadC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2785245..2831063 45818


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14066.04 Da        Isoelectric Point: 7.8045

>T216537 WP_029701676.1 NZ_CP083481:2819241-2819618 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRSNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T216537 NZ_CP113114:c1841294-1841115 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAGAAGCAAGGGGAAAGACTTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13615.39 Da        Isoelectric Point: 7.0264

>AT216537 WP_021553056.1 NZ_CP083481:2818783-2819151 [Escherichia coli]
VSDTLSGTTHPDDNHDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGNRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT216537 NZ_CP113114:c1841078-1840626 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1YPH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0K5N986

References