Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1583721..1584247 Replicon chromosome
Accession NC_008258
Organism Shigella flexneri 5 str. 8401

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag SFV_RS08655 Protein ID WP_000323025.1
Coordinates 1583721..1584008 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag SFV_RS08660 Protein ID WP_000534858.1
Coordinates 1584008..1584247 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SFV_RS08600 1578779..1579114 + 336 WP_000871291.1 anti-adapter protein IraM -
SFV_RS28005 1579395..1579503 - 109 Protein_1582 DUF3927 family protein -
SFV_RS08625 1580423..1581244 - 822 Protein_1583 antitermination protein -
SFV_RS08630 1581259..1581615 - 357 WP_000904111.1 RusA family crossover junction endodeoxyribonuclease -
SFV_RS08635 1581628..1582678 - 1051 Protein_1585 DUF968 domain-containing protein -
SFV_RS08640 1582680..1582958 - 279 Protein_1586 hypothetical protein -
SFV_RS08645 1583025..1583276 - 252 WP_000980987.1 hypothetical protein -
SFV_RS08650 1583494..1583649 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
SFV_RS08655 1583721..1584008 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
SFV_RS08660 1584008..1584247 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
SFV_RS25420 1584272..1584577 + 306 WP_071818640.1 hypothetical protein -
SFV_RS08675 1585792..1586811 + 1020 Protein_1593 MHS family MFS transporter YdfJ -
SFV_RS08680 1586900..1588360 + 1461 WP_000527766.1 mannitol dehydrogenase family protein -
SFV_RS08685 1588396..1588599 - 204 WP_000214712.1 putative selenium delivery protein YdfZ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1567690..1606052 38362


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T21653 WP_000323025.1 NC_008258:c1584008-1583721 [Shigella flexneri 5 str. 8401]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T21653 NC_008258:c1584008-1583721 [Shigella flexneri 5 str. 8401]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT21653 WP_000534858.1 NC_008258:c1584247-1584008 [Shigella flexneri 5 str. 8401]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT21653 NC_008258:c1584247-1584008 [Shigella flexneri 5 str. 8401]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References