Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 570764..571290 | Replicon | chromosome |
| Accession | NZ_CP083481 | ||
| Organism | Escherichia coli strain elppa9 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | K9U12_RS02840 | Protein ID | WP_000323025.1 |
| Coordinates | 571003..571290 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | K9U12_RS02835 | Protein ID | WP_000534858.1 |
| Coordinates | 570764..571003 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K9U12_RS02805 (566026) | 566026..566640 | + | 615 | WP_001265627.1 | hypothetical protein | - |
| K9U12_RS02810 (566643) | 566643..567665 | + | 1023 | WP_000915483.1 | DUF4868 domain-containing protein | - |
| K9U12_RS02815 (568170) | 568170..569240 | + | 1071 | Protein_551 | ISNCY family transposase | - |
| K9U12_RS02820 (569313) | 569313..569462 | + | 150 | WP_011443592.1 | protein YdfW | - |
| K9U12_RS02825 (569899) | 569899..570231 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| K9U12_RS02830 (570434) | 570434..570739 | - | 306 | WP_001326990.1 | protein YdfV | - |
| K9U12_RS02835 (570764) | 570764..571003 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| K9U12_RS02840 (571003) | 571003..571290 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| K9U12_RS02845 (571362) | 571362..571517 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| K9U12_RS02850 (571734) | 571734..571985 | + | 252 | WP_000980994.1 | protein Rem | - |
| K9U12_RS02855 (572052) | 572052..572330 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| K9U12_RS02860 (572332) | 572332..573381 | + | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| K9U12_RS02865 (573395) | 573395..574147 | + | 753 | WP_001047135.1 | antitermination protein | - |
| K9U12_RS02870 (574425) | 574425..574514 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| K9U12_RS02875 (574569) | 574569..574781 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| K9U12_RS02880 (575082) | 575082..575297 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| K9U12_RS02885 (575748) | 575748..576206 | + | 459 | WP_000526135.1 | IS200/IS605-like element IS200C family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 541914..609398 | 67484 | |
| - | flank | IS/Tn | - | - | 575748..576206 | 458 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T216526 WP_000323025.1 NZ_CP083481:571003-571290 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T216526 NZ_CP113105:2566048-2566257 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGATTATTAATATAATAGACGGTCAGGTAACTGTAGCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT216526 WP_000534858.1 NZ_CP083481:570764-571003 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT216526 NZ_CP113105:2565743-2566036 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|