Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-VagC |
| Location | 136323..136948 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP083479 | ||
| Organism | Escherichia coli strain elppa10 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | K9U13_RS23950 | Protein ID | WP_000911313.1 |
| Coordinates | 136323..136721 (-) | Length | 133 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | V0VCB2 |
| Locus tag | K9U13_RS23955 | Protein ID | WP_000450520.1 |
| Coordinates | 136721..136948 (-) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K9U13_RS23935 (132648) | 132648..133145 | + | 498 | WP_000605857.1 | entry exclusion protein | - |
| K9U13_RS23940 (133177) | 133177..133908 | + | 732 | WP_023565183.1 | conjugal transfer complement resistance protein TraT | - |
| K9U13_RS23945 (134161) | 134161..136314 | + | 2154 | WP_000009324.1 | type IV conjugative transfer system coupling protein TraD | - |
| K9U13_RS23950 (136323) | 136323..136721 | - | 399 | WP_000911313.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| K9U13_RS23955 (136721) | 136721..136948 | - | 228 | WP_000450520.1 | toxin-antitoxin system antitoxin VapB | Antitoxin |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | aac(3)-IId / blaTEM-1A / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR / dfrA14 / sul3 / aph(3')-Ia / sitABCD | iroE / iroD / iroC / iroB / iucA / iucB / iucC / iucD / iutA | 1..149801 | 149801 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 14901.15 Da Isoelectric Point: 7.8605
>T216513 WP_000911313.1 NZ_CP083479:c136721-136323 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS
Download Length: 399 bp
>T216513 NZ_CP113096:c6828740-6828171 [Pseudomonas citronellolis]
ATGTTCAGACCGTCACCCATCACCCTGCAGCGCGGTGCGCTGCGCCTGGAGCCCATGGTCGAGGCCGACGTGCCGGACCT
GGTGGCGCTGGCCGAGGCCAACCGCGAGGCGCTGAAGTTCATGAGCGCGCCGCAGCGTCCGGACTGGTACCGCAACAGCC
TCGCCGAGCAGCGCGAGGGGCGCGCCCTGCCGCTGGTGGTGCGCCTGGGCAACCAGTTGGTGGGCACCACCCGCTTCATG
GACTTCCTCCCGGCGCTGCCGGCCTGCGAGATCGGTGGCACCTGGCTGGACGCGGCGCAGCACGGCACCGGGCTGAACGC
CAGCATCAAGTACCTGATGCTGCGCCAGGCCTTCGACAACTGGAAGATGGTCCGCGTGCAGCTGAAGACCGCTGCCAGCA
ACCTGCGCTCGCAGCGCGCCATCGAGAAGCTCGGCGCGGTGCGCGAGGGCGTGCTGCGCAACCACCGGCGCCTGGCCGGC
GGGCGCCTGGACGACAGCGTTCTCTACAGCATCACCGACCTGGAGTGGCCGCAGGTGAAGGCCGCCCTGGAAGCCGGCTT
CATCGGCTGA
ATGTTCAGACCGTCACCCATCACCCTGCAGCGCGGTGCGCTGCGCCTGGAGCCCATGGTCGAGGCCGACGTGCCGGACCT
GGTGGCGCTGGCCGAGGCCAACCGCGAGGCGCTGAAGTTCATGAGCGCGCCGCAGCGTCCGGACTGGTACCGCAACAGCC
TCGCCGAGCAGCGCGAGGGGCGCGCCCTGCCGCTGGTGGTGCGCCTGGGCAACCAGTTGGTGGGCACCACCCGCTTCATG
GACTTCCTCCCGGCGCTGCCGGCCTGCGAGATCGGTGGCACCTGGCTGGACGCGGCGCAGCACGGCACCGGGCTGAACGC
CAGCATCAAGTACCTGATGCTGCGCCAGGCCTTCGACAACTGGAAGATGGTCCGCGTGCAGCTGAAGACCGCTGCCAGCA
ACCTGCGCTCGCAGCGCGCCATCGAGAAGCTCGGCGCGGTGCGCGAGGGCGTGCTGCGCAACCACCGGCGCCTGGCCGGC
GGGCGCCTGGACGACAGCGTTCTCTACAGCATCACCGACCTGGAGTGGCCGCAGGTGAAGGCCGCCCTGGAAGCCGGCTT
CATCGGCTGA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8596.63 Da Isoelectric Point: 4.7513
>AT216513 WP_000450520.1 NZ_CP083479:c136948-136721 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF
Download Length: 228 bp
>AT216513 NZ_CP113096:c6828161-6827301 [Pseudomonas citronellolis]
ATGCCCCTCGACAGCGCCCATGGCGAGCGCACGCGCTTCTGGCGGGCCCAGGAACTGGGCGGCCTGGAGCTGCTGCACGC
GCGCTTCATCGAGCAGCGCTTCGCCCCCCACGTCCACGAAGGCTTCGCCCTGGTGCTGATCGAGCAGGGCGCCCAGCGCT
TCCGCCACCGTGGCGCCGAGCACCTGGCGCCCAGCGGCAGCCTGGTGCTGATCAACCCCGACGAGGTCCACACCGGCTCC
AAGGCCCATGAGGCGGGCTGGTTGTACCGCGGCTTCTACCCGGAGATCGGCCAAGTCGGCAGCGTGCTCGACGAGCTGGA
GCTGGGTGGCCGCGGCCTGCCGACCTTCGACGCCAGCGTGTTGCACGATCCCGAGCTGAGCCGGGCCTTCCTGCACGTGC
ACCGCCTGCTGGAATCCAATGCCAGCAGCCTGGAGCGCCAGACCTGCTGGCGCGAGGCATTGCTGTTGCTGTTCCAGCGC
CACGCGCGGGTGCCCGAGGCGCGCCCGGCCGGACAGGAACCCCAGGCGGTGGCCCGCGCCCGCGAGCTGCTGGCGGCCCG
GCTGGTCGAGCCGCCGTCGCTGGAAGAACTGGCGGCGGCGGTGAACCTGTCGCCCTTCCACTTCGCCCGGGTGTTCCGCA
AGGCCACCGGCCTGCCGCCCCACGCCTGGATCAAGCAACGCCGCCTGGAACAGGCCCGCGCCCTGCTCAAGGGCGGCTGC
GCGCCGGCCTCGGTGGCGGCACAGTTGGGCTACGCCGACCAGAGTCACCTGAGCCGCCAGTTCAAGCAGGCCTACGGCGT
GGCGCCTGGGGAATACCGCCAGGCTTGCGGACGCTCCGGCCTGCCACCCGGCAACCTGTAG
ATGCCCCTCGACAGCGCCCATGGCGAGCGCACGCGCTTCTGGCGGGCCCAGGAACTGGGCGGCCTGGAGCTGCTGCACGC
GCGCTTCATCGAGCAGCGCTTCGCCCCCCACGTCCACGAAGGCTTCGCCCTGGTGCTGATCGAGCAGGGCGCCCAGCGCT
TCCGCCACCGTGGCGCCGAGCACCTGGCGCCCAGCGGCAGCCTGGTGCTGATCAACCCCGACGAGGTCCACACCGGCTCC
AAGGCCCATGAGGCGGGCTGGTTGTACCGCGGCTTCTACCCGGAGATCGGCCAAGTCGGCAGCGTGCTCGACGAGCTGGA
GCTGGGTGGCCGCGGCCTGCCGACCTTCGACGCCAGCGTGTTGCACGATCCCGAGCTGAGCCGGGCCTTCCTGCACGTGC
ACCGCCTGCTGGAATCCAATGCCAGCAGCCTGGAGCGCCAGACCTGCTGGCGCGAGGCATTGCTGTTGCTGTTCCAGCGC
CACGCGCGGGTGCCCGAGGCGCGCCCGGCCGGACAGGAACCCCAGGCGGTGGCCCGCGCCCGCGAGCTGCTGGCGGCCCG
GCTGGTCGAGCCGCCGTCGCTGGAAGAACTGGCGGCGGCGGTGAACCTGTCGCCCTTCCACTTCGCCCGGGTGTTCCGCA
AGGCCACCGGCCTGCCGCCCCACGCCTGGATCAAGCAACGCCGCCTGGAACAGGCCCGCGCCCTGCTCAAGGGCGGCTGC
GCGCCGGCCTCGGTGGCGGCACAGTTGGGCTACGCCGACCAGAGTCACCTGAGCCGCCAGTTCAAGCAGGCCTACGGCGT
GGCGCCTGGGGAATACCGCCAGGCTTGCGGACGCTCCGGCCTGCCACCCGGCAACCTGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|