Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2367789..2368414 Replicon chromosome
Accession NZ_CP083478
Organism Escherichia coli strain elppa10

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K9U13_RS11310 Protein ID WP_000911330.1
Coordinates 2368016..2368414 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag K9U13_RS11305 Protein ID WP_000450524.1
Coordinates 2367789..2368016 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9U13_RS11280 (2363592) 2363592..2364062 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
K9U13_RS11285 (2364062) 2364062..2364634 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
K9U13_RS11290 (2364780) 2364780..2365658 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
K9U13_RS11295 (2365675) 2365675..2366709 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
K9U13_RS11300 (2366922) 2366922..2367635 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
K9U13_RS11305 (2367789) 2367789..2368016 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
K9U13_RS11310 (2368016) 2368016..2368414 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
K9U13_RS11315 (2368561) 2368561..2369424 + 864 WP_001267508.1 neutral zinc metallopeptidase -
K9U13_RS11320 (2369439) 2369439..2371454 + 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
K9U13_RS11325 (2371528) 2371528..2372226 + 699 WP_000679823.1 esterase -
K9U13_RS11330 (2372336) 2372336..2372536 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T216492 WP_000911330.1 NZ_CP083478:2368016-2368414 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T216492 NZ_CP113085:c2539133-2538816 [Pantoea agglomerans]
GTGGCGACGTTAAGGAATATTGAAAGTTTCAGGGATGACTGGCTTAAGGATTATTTTTTATATGGCAAATTTTCCAAAAG
AATACCGTCAAGCCTCTCATCAGCGCTGGCGCGAAAGCTCGACATCATCAATGCGGCGATTAGCTATAAGGATTTAAAGT
CGCCGCCTGGCAATCGTTATGAGGAGCTAAACCCGCCTCTCAAGGGGTATGCTTCAATCAGGGTCAATGAGCAATATCGG
CTGATCTTTAAATGGATAGAAGGTAAGGCCGTTGACCTTTATCTGGATGCTCATAGCTATAAAAAGCACAAGCGATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT216492 WP_000450524.1 NZ_CP083478:2367789-2368016 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT216492 NZ_CP113085:c2538735-2538403 [Pantoea agglomerans]
ATGAACCAGGCGACCCGCAAACCGACCACTGTCGGTGACGTATTACTTTACGAATATCTGGAGCCAACCGGCCTGAAGAT
TCTCGACTTAGCGGAGATGCTCAAAGTGCACCGCAACACCGTCAGCGCTCTGGTCAACAATAACCGGAAGCTGACGCCGG
ATATGGCTTTCAGGCTGGCTGCAGCTTTCGAAACCAGCGTTGAGTTCTGGCTTAATCTGCAAAACAGTGTCGATATCTGG
GAAGTGATGCATGATGCCAGGGCACAGGAGGAGATCAGTCGCGTAACACCGTTGAAGGATTTTCTGGTGCAGAAAGAGAA
TCAGCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References