Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 1325588..1326388 Replicon chromosome
Accession NZ_CP083478
Organism Escherichia coli strain elppa10

Toxin (Protein)


Gene name ataT Uniprot ID F4NNI0
Locus tag K9U13_RS06140 Protein ID WP_000342449.1
Coordinates 1325861..1326388 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag K9U13_RS06135 Protein ID WP_001277108.1
Coordinates 1325588..1325854 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9U13_RS06115 (1321246) 1321246..1321914 + 669 WP_000617723.1 cell division ATP-binding protein FtsE -
K9U13_RS06120 (1321907) 1321907..1322965 + 1059 WP_001042003.1 permease-like cell division protein FtsX -
K9U13_RS06125 (1323210) 1323210..1324064 + 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
K9U13_RS06130 (1324335) 1324335..1325438 + 1104 WP_001021996.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
K9U13_RS06135 (1325588) 1325588..1325854 + 267 WP_001277108.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
K9U13_RS06140 (1325861) 1325861..1326388 + 528 WP_000342449.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
K9U13_RS06145 (1326385) 1326385..1326768 - 384 WP_000778795.1 aspartate 1-decarboxylase autocleavage activator PanM -
K9U13_RS06150 (1327192) 1327192..1328301 + 1110 WP_000827696.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
K9U13_RS06155 (1328349) 1328349..1329275 + 927 WP_001295111.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
K9U13_RS06160 (1329272) 1329272..1330549 + 1278 WP_000803771.1 branched chain amino acid ABC transporter permease LivM -
K9U13_RS06165 (1330546) 1330546..1331313 + 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19691.70 Da        Isoelectric Point: 7.7457

>T216488 WP_000342449.1 NZ_CP083478:1325861-1326388 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNKKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

>T216488 NZ_CP113083:4684195-4684599 [Rhodopseudomonas palustris]
GTGATCGTCATCGACACGTCGGCGATCATTGCGATCTTTCGCGAGGAACCAGAGGCAGCCCAGTTTGCGCGGCTGATCGC
CTCCGACGACCAACCGGTTCTATCCTCGGGCAATTTGCTGGAGACCGCGATCGTTCTTCGTGGACTAAAGGACATTCAGC
CAGCCAAAGCGGAACGATGGCTTGATGACTTTATCGCGGAGGCCGGCATCCGGATCGAGCCCGTGACCACCGAGCAGGCC
GGATATGCGCGTTCGGCGCATTTGCGGTTCGGGAAAGGGACCGGCCACAAAGCAGCTCTCAACTACGGAGATTGCTTCGC
CTATGCGCTGGCCAAAGCTTTGAATGCCCCCTTGCTGTGCAAGGGCAACGACTTTCCGCTGACCGATATTCCGCTTGTCG
CATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT216488 WP_001277108.1 NZ_CP083478:1325588-1325854 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp

>AT216488 NZ_CP113083:4683947-4684198 [Rhodopseudomonas palustris]
ATGCATCTCAACATCAAGAACGACGAAGCTCATCAGTTAGCGACAGAGCTGGCCCGCATGACCGGGGAAAGCCTCACTGC
GGCGGTGACCAATGCGCTGCGCGAACAGCTCGCACGCGAGCATCGTCGCCGCCAAACCGACCAGATCGCGCAACGACTGC
TGAAAATCGGAGGCCGGTACGCCGCATTACCTGACACCGGGAGAACTCCAGACGAGATTCTCGGTTACGATGAGAACGGA
TTGCCCACGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLZ4

Antitoxin

Source ID Structure
PDB 6GTS
PDB 6AJN
PDB 6GTQ
PDB 6GTO
PDB 6GTR
PDB 6AJM
AlphaFold DB A0A829CN24

References