Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1304295..1304881 Replicon chromosome
Accession NZ_CP083478
Organism Escherichia coli strain elppa10

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag K9U13_RS06015 Protein ID WP_042014162.1
Coordinates 1304295..1304525 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag K9U13_RS06020 Protein ID WP_000593555.1
Coordinates 1304522..1304881 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9U13_RS06005 (1300332) 1300332..1303067 + 2736 WP_000149165.1 ribosome-associated ATPase/putative transporter RbbA -
K9U13_RS06010 (1303067) 1303067..1304191 + 1125 WP_001314210.1 ABC transporter permease -
K9U13_RS06015 (1304295) 1304295..1304525 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
K9U13_RS06020 (1304522) 1304522..1304881 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K9U13_RS06025 (1305001) 1305001..1305402 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
K9U13_RS06030 (1305408) 1305408..1306214 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
K9U13_RS06035 (1306211) 1306211..1306975 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
K9U13_RS06040 (1306975) 1306975..1307808 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
K9U13_RS06045 (1307805) 1307805..1308749 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T216487 WP_042014162.1 NZ_CP083478:1304295-1304525 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

>T216487 NZ_CP113083:c4047292-4046762 [Rhodopseudomonas palustris]
ATGGCGGACATAGACGACGCGCCAAACCAGCCACGTTCCCGTCTGTCGGCTCCCGTTCCCCTGACGATTGCACATGATCT
GTCGGCGTTCGATTGCGGCGAGCCGGTGTTGAACGACTGGCTGCGCCAACGGGCACTCAAGAACGAAAGCCGCTTCTCGC
GCACCTACGTGGTGTGCGAGGGCAACCAGGTCGTTGGCTATTTCTGCGTTTCAGCGGGCGCGGTCGAGCGCGCCGCAGCG
CCGGGCAAGGTCCGCCGCAACGCGCCCGACGCGATCCCGGTGTCGGTGATCGGGCGACTGGCCGTCAGCCGCTCCCATGC
CGGAATAGGTCTCGGCGCCGACCTGCTTTCGGACGCGCTACGCCGGATCGCGCTGGCGTCGCAGAGCATCGGCATCGGCG
CTGTTCAGGTCCACGCCAAGGACGATGCGGCCAAACGCTTTTATCTGCGCTGCGCCGAATTCATCGAATATCCCCAAGAC
AGCCGGACGCTGTTCCTGCCGATCGAAACGGTAGTCGCGGCCTTGAGTTAG

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT216487 WP_000593555.1 NZ_CP083478:1304522-1304881 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT216487 NZ_CP113083:c4047618-4047280 [Rhodopseudomonas palustris]
ATGGCAAAGTCGCGTGGCGCACCTGCAAAATCCGCTCGTCGTTCCGCTGCGGCCGCAGCGCGCGGCGCGACGTCTGACGC
CAAGGGCAGCATCAATCTGCGGATCGAGACGGGCACTCGCCAGCTCATCGACGATGCGGCGGCGGTCCTTGGGAAGACGC
GCACGGAATTCATGGTGGAGAGCGCCCGGCGGCAGGCGGTCGATGTGCTGCTCGATCAGCGCTTATTCACGCTCGATCCC
GAACGCTATGACGCCTTCATGCAGGCGCTCGACAATCCGCCCGCGCCGGGGCCGAAACTCAAGGCGTTGCTGCGTCGGGT
CCCGGCATGGCGGACATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References