Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | Txe-Axe/Txe-RelB |
| Location | 165065..165584 | Replicon | plasmid pHJP554-1 |
| Accession | NZ_CP083474 | ||
| Organism | Enterococcus faecium strain HJP554 | ||
Toxin (Protein)
| Gene name | Txe | Uniprot ID | Q848U6 |
| Locus tag | LA367_RS14945 | Protein ID | WP_000588503.1 |
| Coordinates | 165065..165322 (-) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | Axe | Uniprot ID | Q83WJ8 |
| Locus tag | LA367_RS14950 | Protein ID | WP_000388479.1 |
| Coordinates | 165315..165584 (-) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LA367_RS14905 | 160123..160359 | - | 237 | WP_224198013.1 | bacteriophage abortive infection AbiH family protein | - |
| LA367_RS14910 | 160383..160997 | - | 615 | WP_065305703.1 | recombinase family protein | - |
| LA367_RS14915 | 161150..161740 | - | 591 | WP_065305702.1 | recombinase family protein | - |
| LA367_RS14920 | 161951..162154 | - | 204 | WP_002299573.1 | hypothetical protein | - |
| LA367_RS14925 | 162164..162586 | - | 423 | WP_002303116.1 | hypothetical protein | - |
| LA367_RS14930 | 162824..163438 | + | 615 | WP_001261742.1 | recombinase family protein | - |
| LA367_RS14935 | 163603..164427 | - | 825 | WP_001809248.1 | hypothetical protein | - |
| LA367_RS14940 | 164451..164606 | - | 156 | WP_002347142.1 | hypothetical protein | - |
| LA367_RS14945 | 165065..165322 | - | 258 | WP_000588503.1 | Txe/YoeB family addiction module toxin | Toxin |
| LA367_RS14950 | 165315..165584 | - | 270 | WP_000388479.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| LA367_RS14955 | 165715..165894 | - | 180 | WP_001120991.1 | hypothetical protein | - |
| LA367_RS14960 | 165910..166110 | - | 201 | WP_002347143.1 | hypothetical protein | - |
| LA367_RS14965 | 166275..166982 | - | 708 | WP_002303117.1 | hypothetical protein | - |
| LA367_RS14970 | 166975..167412 | - | 438 | WP_002300851.1 | hypothetical protein | - |
| LA367_RS14975 | 167427..167678 | - | 252 | WP_002296238.1 | hypothetical protein | - |
| LA367_RS14980 | 167678..167884 | - | 207 | WP_002347218.1 | hypothetical protein | - |
| LA367_RS14985 | 168321..168581 | - | 261 | WP_002295623.1 | hypothetical protein | - |
| LA367_RS14990 | 168755..168859 | + | 105 | WP_008274030.1 | putative holin-like toxin | - |
| LA367_RS14995 | 169000..169485 | - | 486 | WP_002303313.1 | single-stranded DNA-binding protein | - |
| LA367_RS15000 | 169488..170387 | - | 900 | WP_002303312.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..196609 | 196609 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10206.53 Da Isoelectric Point: 8.4369
>T216482 WP_000588503.1 NZ_CP083474:c165322-165065 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
Download Length: 258 bp
>T216482 NZ_CP113079:16685-17044 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10373.51 Da Isoelectric Point: 4.4346
>AT216482 WP_000388479.1 NZ_CP083474:c165584-165315 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
Download Length: 270 bp
>AT216482 NZ_CP113079:17044-17343 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A828ZXQ8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A828ZWU7 |