Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 165065..165584 Replicon plasmid pHJP554-1
Accession NZ_CP083474
Organism Enterococcus faecium strain HJP554

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag LA367_RS14945 Protein ID WP_000588503.1
Coordinates 165065..165322 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag LA367_RS14950 Protein ID WP_000388479.1
Coordinates 165315..165584 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA367_RS14905 160123..160359 - 237 WP_224198013.1 bacteriophage abortive infection AbiH family protein -
LA367_RS14910 160383..160997 - 615 WP_065305703.1 recombinase family protein -
LA367_RS14915 161150..161740 - 591 WP_065305702.1 recombinase family protein -
LA367_RS14920 161951..162154 - 204 WP_002299573.1 hypothetical protein -
LA367_RS14925 162164..162586 - 423 WP_002303116.1 hypothetical protein -
LA367_RS14930 162824..163438 + 615 WP_001261742.1 recombinase family protein -
LA367_RS14935 163603..164427 - 825 WP_001809248.1 hypothetical protein -
LA367_RS14940 164451..164606 - 156 WP_002347142.1 hypothetical protein -
LA367_RS14945 165065..165322 - 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
LA367_RS14950 165315..165584 - 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LA367_RS14955 165715..165894 - 180 WP_001120991.1 hypothetical protein -
LA367_RS14960 165910..166110 - 201 WP_002347143.1 hypothetical protein -
LA367_RS14965 166275..166982 - 708 WP_002303117.1 hypothetical protein -
LA367_RS14970 166975..167412 - 438 WP_002300851.1 hypothetical protein -
LA367_RS14975 167427..167678 - 252 WP_002296238.1 hypothetical protein -
LA367_RS14980 167678..167884 - 207 WP_002347218.1 hypothetical protein -
LA367_RS14985 168321..168581 - 261 WP_002295623.1 hypothetical protein -
LA367_RS14990 168755..168859 + 105 WP_008274030.1 putative holin-like toxin -
LA367_RS14995 169000..169485 - 486 WP_002303313.1 single-stranded DNA-binding protein -
LA367_RS15000 169488..170387 - 900 WP_002303312.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..196609 196609


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T216482 WP_000588503.1 NZ_CP083474:c165322-165065 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T216482 NZ_CP113079:16685-17044 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT216482 WP_000388479.1 NZ_CP083474:c165584-165315 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT216482 NZ_CP113079:17044-17343 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References