Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 102783..104351 | Replicon | plasmid p158496 |
| Accession | NZ_CP083462 | ||
| Organism | Aeromonas veronii strain SW3814 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | A0A764ZV95 |
| Locus tag | LAG74_RS22130 | Protein ID | WP_025989278.1 |
| Coordinates | 103044..104351 (+) | Length | 436 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | - |
| Locus tag | LAG74_RS22125 | Protein ID | WP_012766359.1 |
| Coordinates | 102783..103034 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LAG74_RS22095 (LAG74_22135) | 98215..98814 | + | 600 | WP_012766354.1 | hypothetical protein | - |
| LAG74_RS22100 (LAG74_22140) | 99379..99831 | + | 453 | WP_012766355.1 | hypothetical protein | - |
| LAG74_RS22105 (LAG74_22145) | 99847..100449 | - | 603 | WP_012766356.1 | hypothetical protein | - |
| LAG74_RS22110 (LAG74_22150) | 100710..100853 | + | 144 | Protein_127 | hypothetical protein | - |
| LAG74_RS22115 (LAG74_22155) | 100865..101395 | + | 531 | WP_012766357.1 | hypothetical protein | - |
| LAG74_RS22120 (LAG74_22160) | 101398..102402 | + | 1005 | WP_012766358.1 | tyrosine-type recombinase/integrase | - |
| LAG74_RS22125 (LAG74_22165) | 102783..103034 | + | 252 | WP_012766359.1 | helix-turn-helix domain-containing protein | Antitoxin |
| LAG74_RS22130 (LAG74_22170) | 103044..104351 | + | 1308 | WP_025989278.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| LAG74_RS22135 (LAG74_22175) | 104348..104842 | + | 495 | WP_012766361.1 | hypothetical protein | - |
| LAG74_RS22140 (LAG74_22180) | 105014..105952 | - | 939 | WP_012766362.1 | hypothetical protein | - |
| LAG74_RS22145 (LAG74_22185) | 106196..107791 | + | 1596 | WP_242427778.1 | PAAR domain-containing protein | - |
| LAG74_RS22150 (LAG74_22190) | 108190..108489 | - | 300 | WP_012766365.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | aph(6)-Id / dfrA12 / aadA2 / qacE / sul1 / mph(A) / blaVEB-3 / tet(D) | - | 1..158496 | 158496 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 436 a.a. Molecular weight: 47938.15 Da Isoelectric Point: 6.3142
>T216478 WP_025989278.1 NZ_CP083462:103044-104351 [Aeromonas veronii]
MQTLTVAMNGEVVGTLYRDNKGAMSFQYAPEWISEPGSRAISMSLPLGHGRITGSEVFNFFSNLLPDSEAIIARMQARFR
VETTHPFDLLASVGRDCVGAIQLYSPDADIPTVMETLAEPLDEAQIEQLLEGYQEAPLGMAEDADFRISIAGAQEKTALL
WYQDRWQRPLGSTPTSHIFKLPIGKIVQNNIDLSESCENEWLCLRIAKAFGFDVANADLATFGKKKVLVVQRFDRRWSKS
GEWLLRLPQEDFCQALGIAPALKYESHGGPGIADAMKLLLGSRFAAKDREQFFKSQILFWMLAAIDGHGKNFSIFIEPAS
SFRMTPLYDVMSAFPIFKSGGIAAQKAKMGMALQGKNRQYRFAMIQPRHFISTAAHVGFPPDTAAQLMLDMATKTEEVVA
TVAAELPAGFPEHISSAIFEGLSSQAAKILKGVAK
MQTLTVAMNGEVVGTLYRDNKGAMSFQYAPEWISEPGSRAISMSLPLGHGRITGSEVFNFFSNLLPDSEAIIARMQARFR
VETTHPFDLLASVGRDCVGAIQLYSPDADIPTVMETLAEPLDEAQIEQLLEGYQEAPLGMAEDADFRISIAGAQEKTALL
WYQDRWQRPLGSTPTSHIFKLPIGKIVQNNIDLSESCENEWLCLRIAKAFGFDVANADLATFGKKKVLVVQRFDRRWSKS
GEWLLRLPQEDFCQALGIAPALKYESHGGPGIADAMKLLLGSRFAAKDREQFFKSQILFWMLAAIDGHGKNFSIFIEPAS
SFRMTPLYDVMSAFPIFKSGGIAAQKAKMGMALQGKNRQYRFAMIQPRHFISTAAHVGFPPDTAAQLMLDMATKTEEVVA
TVAAELPAGFPEHISSAIFEGLSSQAAKILKGVAK
Download Length: 1308 bp
>T216478 NZ_CP113075:c1658-1302 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGTACAGCAAGATGAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ACATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCATTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAACT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGTACAGCAAGATGAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ACATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCATTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAACT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9380.82 Da Isoelectric Point: 9.8930
>AT216478 WP_012766359.1 NZ_CP083462:102783-103034 [Aeromonas veronii]
MKVTSPSLLAAAVRDQRKLSKLTQSEAAKQVGIKQTTVSDFELRPESTKLETLFKLLAALDLELHVVKRGSTLDDNKVWD
REW
MKVTSPSLLAAAVRDQRKLSKLTQSEAAKQVGIKQTTVSDFELRPESTKLETLFKLLAALDLELHVVKRGSTLDDNKVWD
REW
Download Length: 252 bp
>AT216478 NZ_CP113075:c1309-1007 [Acinetobacter baumannii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAAAAAATGGCTGATGAATT
ACTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCGTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTTGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTTAATGTCTAA
ATGGCTAAGACCCTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAAAAAATGGCTGATGAATT
ACTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCGTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTTGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTTAATGTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|