Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 372280..372928 Replicon chromosome
Accession NZ_CP083454
Organism Stenotrophomonas maltophilia strain XL133

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag LAD79_RS01685 Protein ID WP_005407702.1
Coordinates 372280..372585 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag LAD79_RS01690 Protein ID WP_005407703.1
Coordinates 372626..372928 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAD79_RS01660 (LAD79_01660) 367566..368414 + 849 WP_062606017.1 SPOR domain-containing protein -
LAD79_RS01670 (LAD79_01670) 369008..369679 - 672 WP_005407700.1 hypothetical protein -
LAD79_RS01675 (LAD79_01675) 369770..371275 - 1506 WP_005407701.1 hypothetical protein -
LAD79_RS01685 (LAD79_01685) 372280..372585 + 306 WP_005407702.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LAD79_RS01690 (LAD79_01690) 372626..372928 + 303 WP_005407703.1 putative addiction module antidote protein Antitoxin
LAD79_RS01695 (LAD79_01695) 373186..373485 - 300 WP_005407704.1 hypothetical protein -
LAD79_RS01700 (LAD79_01700) 373566..373973 - 408 WP_043035194.1 hypothetical protein -
LAD79_RS01705 (LAD79_01705) 374568..375338 + 771 WP_005411960.1 DUF3011 domain-containing protein -
LAD79_RS01710 (LAD79_01710) 375363..375710 - 348 WP_005411961.1 hypothetical protein -
LAD79_RS01715 (LAD79_01715) 375841..376761 + 921 WP_100438271.1 arginase -
LAD79_RS01720 (LAD79_01720) 376922..377059 + 138 WP_005407710.1 entericidin A/B family lipoprotein -
LAD79_RS01725 (LAD79_01725) 377266..377487 + 222 WP_004153772.1 CsbD family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-90)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-95)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11444.15 Da        Isoelectric Point: 10.9897

>T216475 WP_005407702.1 NZ_CP083454:372280-372585 [Stenotrophomonas maltophilia]
MKIQRTRQFATWIDALKDVTARARILARIGRLAEGHPGDHRYLADGVSELRIDAGPGYRVYYTQRGRQLVILLVGGDKGS
QQRDIEKAKEIARALRASNWL

Download         Length: 306 bp

>T216475 NZ_CP113073:450218-450607 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCAAAAATTGCCTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACTATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTACTTTGAAGATCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGTAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10703.27 Da        Isoelectric Point: 7.2780

>AT216475 WP_005407703.1 NZ_CP083454:372626-372928 [Stenotrophomonas maltophilia]
MAIKKKVELEAFDVAEHLHTPKEMAAYLDACIEESDGDSAFIAKALGDIARAQGMSKVARAAGLSRESLYRALSGERSPD
FSTILKVTRALGVRLHASAA

Download         Length: 303 bp

>AT216475 NZ_CP113073:449954-450211 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References