Detailed information of TA system TA216473

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/HTH_IclR(antitoxin)
• Location: 4193297..4195027
• Replicon: chromosome
• Accession: NZ_CP083451
• Organism: Comamonas odontotermitis strain WLL

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: LAD35_RS19245
• Protein ID: WP_224150540.1
• Coordinates: 4194149..4195027 (-)
• Length: 293 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: -
• Locus tag: LAD35_RS19240
• Protein ID: WP_184704287.1
• Coordinates: 4193297..4194133 (-)
• Length: 279 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LAD35_RS19225 (LAD35_19225)	4189785..4190582	-	798	WP_224150537.1	aspartate dehydrogenase	-
LAD35_RS19230 (LAD35_19230)	4190622..4192316	-	1695	WP_224150538.1	thiamine pyrophosphate-binding protein	-
LAD35_RS19235 (LAD35_19235)	4192474..4193283	-	810	WP_224150539.1	SDR family oxidoreductase	-
LAD35_RS19240 (LAD35_19240)	4193297..4194133	-	837	WP_184704287.1	IclR family transcriptional regulator	Antitoxin
LAD35_RS19245 (LAD35_19245)	4194149..4195027	-	879	WP_224150540.1	alpha/beta hydrolase	Toxin
LAD35_RS19250 (LAD35_19250)	4195046..4195576	-	531	WP_224150541.1	cupin domain-containing protein	-
LAD35_RS19255 (LAD35_19255)	4195593..4196369	-	777	WP_184704292.1	SDR family oxidoreductase	-
LAD35_RS19260 (LAD35_19260)	4196616..4197827	-	1212	WP_224150542.1	MFS transporter	-
LAD35_RS19265 (LAD35_19265)	4197914..4198672	-	759	WP_224150543.1	5'-methylthioadenosine/adenosylhomocysteine nucleosidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Alpha/beta hydrolase fold-1 (52-284)

Antitoxin

• Transcription regulator IclR, N-terminal (18-67)

Sequences

Toxin

Protein

• Length: 293 a.a.
• Molecular weight: 30950.10 Da
• Isoelectric Point: 6.6541

>T216473 WP_224150540.1 NZ_CP083451:c4195027-4194149 [Comamonas odontotermitis]
MTTDTATLWSEALMRKAQQLESQFAQRSVALPDGVQLAVRERPAAGVAAQTVVLLHGISSSAASWLDVALALRPDWRVLA
WDAPGYGSSTALPQTHPHDTDYAARLGAWLAAEVRGPVVLVGHSLGALMAAACAAQYAPQALAGVLLLSPAGGYGSHDVA
AREKVRSERNASLDTLGVAGLAQRIDQRLLSPGADALAREWVRWSTSRMHDGGYRQAVNMLCDSDLGRHAPLPVPVHIAC
GEHDVVTTPAACRRWAGAWQVPFSSIADAGHASPVEKPGAVAEWIEDRAFLL

Nucleotide

• Length: 879 bp

>T216473 NZ_CP113071:c3301365-3300976 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCAAAAATTGCCTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACTATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTACTTTGAAGATCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGTAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 279 a.a.
• Molecular weight: 30348.70 Da
• Isoelectric Point: 6.4990

>AT216473 WP_184704287.1 NZ_CP083451:c4194133-4193297 [Comamonas odontotermitis]
MTQTNPSETGSEKYVVPALERGLRLLQEFGRDSRTLGAPELARRLELPRATVFRMLNTLEGMGFLERIDGGTEYRLGMAV
LRLGFEYLSSLELTELGQPVIARLCDEISYPCNIVVRDNRSIVYVAKVTPPRPLASAVHVGTRLAAHGTVFGRVLLLDFS
LAELRALYPEEHLEAFSPNTPRTALDLFNLIEVDRERGYVFGEGFYETSISTVAAPVRDHSGRIVAALGSTIPSPHAGQA
KAAGVAERVCAAADELSGLLNYRREAQAGARVLSMPGH

Nucleotide

• Length: 837 bp

>AT216473 NZ_CP113071:c3301629-3301372 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA