Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1931919..1932616 Replicon chromosome
Accession NZ_CP083451
Organism Comamonas odontotermitis strain WLL

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LAD35_RS09015 Protein ID WP_224152342.1
Coordinates 1932200..1932616 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID -
Locus tag LAD35_RS09010 Protein ID WP_224152341.1
Coordinates 1931919..1932176 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAD35_RS08990 (LAD35_08990) 1926973..1928259 + 1287 WP_224152337.1 TIGR03862 family flavoprotein -
LAD35_RS08995 (LAD35_08995) 1928262..1928726 + 465 WP_224152338.1 acetyltransferase -
LAD35_RS09000 (LAD35_09000) 1928857..1929492 - 636 WP_224152339.1 GntR family transcriptional regulator -
LAD35_RS09005 (LAD35_09005) 1929697..1931871 + 2175 WP_224152340.1 methylmalonyl-CoA mutase -
LAD35_RS09010 (LAD35_09010) 1931919..1932176 + 258 WP_224152341.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
LAD35_RS09015 (LAD35_09015) 1932200..1932616 + 417 WP_224152342.1 PIN domain-containing protein Toxin
LAD35_RS09020 (LAD35_09020) 1932613..1933071 + 459 WP_224152343.1 GNAT family N-acetyltransferase -
LAD35_RS09025 (LAD35_09025) 1933164..1934201 + 1038 WP_224152344.1 methylmalonyl Co-A mutase-associated GTPase MeaB -
LAD35_RS09030 (LAD35_09030) 1934296..1935828 + 1533 WP_184710260.1 acyl-CoA carboxylase subunit beta -
LAD35_RS09035 (LAD35_09035) 1935847..1936503 + 657 WP_224152345.1 hypothetical protein -
LAD35_RS09040 (LAD35_09040) 1936511..1937485 + 975 WP_224152346.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(10-46)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15587.90 Da        Isoelectric Point: 5.9093

>T216472 WP_224152342.1 NZ_CP083451:1932200-1932616 [Comamonas odontotermitis]
MPRYYLDTNICIYAWHRQHAAVLARMRAVDHTRMVISALVAAELASGVMRSTHVERNRVLMEEALSLFSIEPWGGDAIWH
YGEQSARLRKAGTPIGAIDLMIGCQALADPDGVLVTHNVREFERIEGLRIEDWMEAAE

Download         Length: 417 bp

>T216472 NZ_CP113070:c3301912-3301523 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAGCTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCAAAAATTGCCTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACTATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTACTTTGAAGATCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGTAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9552.87 Da        Isoelectric Point: 4.8485

>AT216472 WP_224152341.1 NZ_CP083451:1931919-1932176 [Comamonas odontotermitis]
MSDLAIAKVFMNGRSQAVRLPKEFRFDTEEVTVERQADGAVVLRPVPADAHAAWLARLDKVLGRFEGMPDEIERDKTPPR
DVGFD

Download         Length: 258 bp

>AT216472 NZ_CP113070:c3302176-3301919 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References