Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 837141..837810 Replicon chromosome
Accession NZ_CP083451
Organism Comamonas odontotermitis strain WLL

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LAD35_RS03865 Protein ID WP_224151398.1
Coordinates 837631..837810 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LAD35_RS03860 Protein ID WP_224151397.1
Coordinates 837141..837566 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAD35_RS03820 (LAD35_03820) 832439..832990 + 552 WP_224151389.1 hypothetical protein -
LAD35_RS03825 (LAD35_03825) 833051..833308 + 258 WP_224151390.1 hypothetical protein -
LAD35_RS03830 (LAD35_03830) 833292..833927 + 636 WP_224151391.1 endolysin -
LAD35_RS03835 (LAD35_03835) 834020..834559 + 540 WP_224151392.1 hypothetical protein -
LAD35_RS03840 (LAD35_03840) 834602..834781 - 180 WP_224151393.1 hypothetical protein -
LAD35_RS03845 (LAD35_03845) 834886..835116 - 231 WP_224151394.1 hypothetical protein -
LAD35_RS03850 (LAD35_03850) 835635..836123 - 489 WP_224151395.1 GNAT family protein -
LAD35_RS03855 (LAD35_03855) 836510..837031 - 522 WP_224151396.1 hypothetical protein -
LAD35_RS03860 (LAD35_03860) 837141..837566 - 426 WP_224151397.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LAD35_RS03865 (LAD35_03865) 837631..837810 - 180 WP_224151398.1 type II toxin-antitoxin system HicA family toxin Toxin
LAD35_RS03870 (LAD35_03870) 837935..838225 + 291 WP_224152576.1 hypothetical protein -
LAD35_RS03875 (LAD35_03875) 838369..838557 - 189 WP_224151399.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 814380..838557 24177


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-82)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6771.83 Da        Isoelectric Point: 10.9929

>T216471 WP_224151398.1 NZ_CP083451:c837810-837631 [Comamonas odontotermitis]
VKQSEFRRYLASLGATFQEGARHTKVYLNGKQTVMPRHPSRELMEGTRKAILKQLGINE

Download         Length: 180 bp

>T216471 NZ_CP113069:443602-443991 [Acinetobacter baumannii]
TTGCTCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATAAGCTTTATTTTCTTTT
TAAAGCGTCCGCAACTTGCAAAAATTGCCTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAACTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15373.62 Da        Isoelectric Point: 4.3648

>AT216471 WP_224151397.1 NZ_CP083451:c837566-837141 [Comamonas odontotermitis]
MKYPALFTEAPEGGYTVTFRDIPEAITEGQTLEEAREMAADALLTAMDFYFEDGRAVPDPSAPEAGEELVALPLSVWAKV
QLLNLRIQKNARPADIARAMGIKPQEVTRILDLHHATKIDTLAAAFHAMDSELSIAVIPAI

Download         Length: 426 bp

>AT216471 NZ_CP113069:443338-443595 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References