Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 853233..853853 Replicon chromosome
Accession NZ_CP083448
Organism Pantoea eucrina strain XL123

Toxin (Protein)


Gene name Hha Uniprot ID A0A2S5KCC4
Locus tag LAC65_RS03920 Protein ID WP_039383002.1
Coordinates 853233..853451 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2S5KBQ5
Locus tag LAC65_RS03925 Protein ID WP_039383003.1
Coordinates 853476..853853 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAC65_RS03890 (LAC65_03890) 849201..849539 + 339 WP_003850469.1 P-II family nitrogen regulator -
LAC65_RS03895 (LAC65_03895) 849572..850861 + 1290 WP_039385741.1 ammonium transporter AmtB -
LAC65_RS03900 (LAC65_03900) 850903..851766 - 864 WP_039382999.1 acyl-CoA thioesterase II -
LAC65_RS03905 (LAC65_03905) 851970..852527 + 558 WP_224144833.1 YbaY family lipoprotein -
LAC65_RS03910 (LAC65_03910) 852564..852875 - 312 WP_039383001.1 MGMT family protein -
LAC65_RS03920 (LAC65_03920) 853233..853451 - 219 WP_039383002.1 HHA domain-containing protein Toxin
LAC65_RS03925 (LAC65_03925) 853476..853853 - 378 WP_039383003.1 Hha toxicity modulator TomB Antitoxin
LAC65_RS03930 (LAC65_03930) 853999..854352 - 354 WP_039385744.1 hypothetical protein -
LAC65_RS03935 (LAC65_03935) 854670..855311 + 642 WP_039383005.1 ATP-binding cassette domain-containing protein -
LAC65_RS03940 (LAC65_03940) 855308..856147 + 840 WP_039383006.1 metal ABC transporter permease -
LAC65_RS03945 (LAC65_03945) 856169..857047 + 879 WP_224144834.1 metal ABC transporter substrate-binding protein -
LAC65_RS03950 (LAC65_03950) 857088..857228 - 141 WP_071668939.1 type B 50S ribosomal protein L36 -
LAC65_RS03955 (LAC65_03955) 857241..857498 - 258 WP_039383008.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8571.90 Da        Isoelectric Point: 9.4242

>T216467 WP_039383002.1 NZ_CP083448:c853451-853233 [Pantoea eucrina]
MSNQTLTKTDYLMRLRRCRSIDTLERVIEKNKYELPDSELAVFYSAADHRLAELTMNKLYDKVPGSVWKYVR

Download         Length: 219 bp

>T216467 NZ_CP113052:c618622-618515 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14797.42 Da        Isoelectric Point: 4.5129

>AT216467 WP_039383003.1 NZ_CP083448:c853853-853476 [Pantoea eucrina]
MDEYSPKRHDIAQLKFLCENLYDESMATLSENHRDWVNDPASSANLQLNDFIEHIASFTMNYKIKHTEDESLISQIDEYL
DDTFMLFSSYSINAKDLQRWQRSAKRLFNIFAEECAYLQQPSHSF

Download         Length: 378 bp

>AT216467 NZ_CP113052:618438-618498 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S5KCC4

Antitoxin

Source ID Structure
AlphaFold DB A0A2S5KBQ5

References