Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 738516..739229 Replicon chromosome
Accession NZ_CP083448
Organism Pantoea eucrina strain XL123

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag LAC65_RS03360 Protein ID WP_148810983.1
Coordinates 738516..738878 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag LAC65_RS03365 Protein ID WP_148810982.1
Coordinates 738903..739229 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAC65_RS03345 (LAC65_03345) 735449..736450 + 1002 WP_224144826.1 BsuBI/PstI family type II restriction endonuclease -
LAC65_RS03350 (LAC65_03350) 736500..738029 - 1530 WP_224144827.1 Eco57I restriction-modification methylase domain-containing protein -
LAC65_RS03355 (LAC65_03355) 738164..738424 - 261 Protein_634 restriction endonuclease subunit M -
LAC65_RS03360 (LAC65_03360) 738516..738878 - 363 WP_148810983.1 TA system toxin CbtA family protein Toxin
LAC65_RS03365 (LAC65_03365) 738903..739229 - 327 WP_148810982.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LAC65_RS03370 (LAC65_03370) 739243..739719 - 477 WP_148810981.1 DNA repair protein RadC -
LAC65_RS03375 (LAC65_03375) 739730..740176 - 447 WP_224144828.1 antirestriction protein -
LAC65_RS03380 (LAC65_03380) 740400..741089 - 690 WP_224144829.1 hypothetical protein -
LAC65_RS03385 (LAC65_03385) 741409..741582 + 174 WP_224144830.1 hypothetical protein -
LAC65_RS03390 (LAC65_03390) 741624..742592 - 969 WP_000654812.1 IS5-like element IS903B family transposase -
LAC65_RS03395 (LAC65_03395) 742744..744117 - 1374 WP_148810970.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 730304..750726 20422
- flank IS/Tn - - 741624..742592 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-105)

Antitoxin

Antitoxin CbeA

(8-107)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13557.67 Da        Isoelectric Point: 7.8847

>T216466 WP_148810983.1 NZ_CP083448:c738878-738516 [Pantoea eucrina]
MKILPATTQRAAKPCPSPVTVWQMLLTRLLEQHYGLTLNDTPFSDETVIQEHINAGITLADAVNFLVDKYELVRIDRRGL
SWQEQSPYLRAVDILRARQATGLLRGGIIFRHAESCVQLS

Download         Length: 363 bp

>T216466 NZ_CP113052:c593356-593090 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12336.08 Da        Isoelectric Point: 6.6249

>AT216466 WP_148810982.1 NZ_CP083448:c739229-738903 [Pantoea eucrina]
MPLTDVIQWGLQRNFTPNFGARLVQEGNRLHYLADRASITGKFGDAECLKLEEAFPHFIRQMELMLSTGELNPRHSHCVT
LYHNAFTCEADTLGSCGYVYIVIYPTQR

Download         Length: 327 bp

>AT216466 NZ_CP113052:c593607-593356 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGTTATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References