Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 5190003..5191591 Replicon chromosome
Accession NZ_CP083445
Organism Klebsiella pneumoniae strain KP294

Toxin (Protein)


Gene name hipA Uniprot ID A0A486KW17
Locus tag LAV94_RS25440 Protein ID WP_004190166.1
Coordinates 5190003..5191325 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag LAV94_RS25445 Protein ID WP_002904790.1
Coordinates 5191325..5191591 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAV94_RS25425 (5185059) 5185059..5187560 + 2502 WP_004190161.1 fimbria/pilus outer membrane usher protein -
LAV94_RS25430 (5187548) 5187548..5188552 + 1005 WP_004190163.1 fimbrial protein -
LAV94_RS25435 (5188694) 5188694..5189986 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
LAV94_RS25440 (5190003) 5190003..5191325 - 1323 WP_004190166.1 type II toxin-antitoxin system HipA family toxin Toxin
LAV94_RS25445 (5191325) 5191325..5191591 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LAV94_RS25450 (5191856) 5191856..5192182 - 327 WP_004143476.1 hydroxyisourate hydrolase -
LAV94_RS25455 (5192179) 5192179..5192679 - 501 WP_004190169.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LAV94_RS25460 (5192657) 5192657..5194036 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
LAV94_RS25465 (5194382) 5194382..5195536 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LAV94_RS25470 (5195517) 5195517..5196440 - 924 WP_004190172.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49171.46 Da        Isoelectric Point: 7.5357

>T216465 WP_004190166.1 NZ_CP083445:c5191325-5190003 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T216465 NZ_CP113052:c328599-328495 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT216465 WP_002904790.1 NZ_CP083445:c5191591-5191325 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT216465 NZ_CP113052:328401-328439 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486KW17

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References