Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3437688..3438345 Replicon chromosome
Accession NZ_CP083445
Organism Klebsiella pneumoniae strain KP294

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LAV94_RS16860 Protein ID WP_002916310.1
Coordinates 3437935..3438345 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LAV94_RS16855 Protein ID WP_002916312.1
Coordinates 3437688..3437954 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAV94_RS16830 (3432844) 3432844..3434277 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
LAV94_RS16835 (3434396) 3434396..3435124 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LAV94_RS16840 (3435174) 3435174..3435485 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
LAV94_RS16845 (3435649) 3435649..3436308 + 660 WP_002916317.1 hemolysin III family protein -
LAV94_RS16850 (3436459) 3436459..3437442 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LAV94_RS16855 (3437688) 3437688..3437954 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LAV94_RS16860 (3437935) 3437935..3438345 + 411 WP_002916310.1 protein YgfX Toxin
LAV94_RS16865 (3438352) 3438352..3438873 - 522 WP_002916308.1 flavodoxin FldB -
LAV94_RS16870 (3438974) 3438974..3439870 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LAV94_RS16875 (3439893) 3439893..3440606 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LAV94_RS16880 (3440612) 3440612..3442345 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T216456 WP_002916310.1 NZ_CP083445:3437935-3438345 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T216456 NZ_CP113051:c1776900-1776691 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT216456 WP_002916312.1 NZ_CP083445:3437688-3437954 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT216456 NZ_CP113051:c1777205-1776912 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References