Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2065791..2066307 Replicon chromosome
Accession NZ_CP083445
Organism Klebsiella pneumoniae strain KP294

Toxin (Protein)


Gene name relE Uniprot ID A0A486Q7B5
Locus tag LAV94_RS10170 Protein ID WP_004192395.1
Coordinates 2065791..2066075 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A483GCT9
Locus tag LAV94_RS10175 Protein ID WP_004192397.1
Coordinates 2066065..2066307 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAV94_RS10145 (2061208) 2061208..2061471 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
LAV94_RS10150 (2061601) 2061601..2061774 + 174 WP_002886906.1 hypothetical protein -
LAV94_RS10155 (2061777) 2061777..2062520 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LAV94_RS10160 (2062877) 2062877..2065015 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LAV94_RS10165 (2065323) 2065323..2065787 + 465 WP_004192393.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LAV94_RS10170 (2065791) 2065791..2066075 - 285 WP_004192395.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LAV94_RS10175 (2066065) 2066065..2066307 - 243 WP_004192397.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LAV94_RS10180 (2066385) 2066385..2068295 - 1911 WP_004152270.1 PRD domain-containing protein -
LAV94_RS10185 (2068318) 2068318..2069472 - 1155 WP_004178372.1 lactonase family protein -
LAV94_RS10190 (2069539) 2069539..2070279 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11184.03 Da        Isoelectric Point: 10.3787

>T216450 WP_004192395.1 NZ_CP083445:c2066075-2065791 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQVNKRL

Download         Length: 285 bp

>T216450 NZ_CP113051:c409475-409287 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9073.60 Da        Isoelectric Point: 6.3340

>AT216450 WP_004192397.1 NZ_CP083445:c2066307-2066065 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEVVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT216450 NZ_CP113051:c409764-409504 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACTACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486Q7B5

Antitoxin

Source ID Structure
AlphaFold DB A0A483GCT9

References