Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1360651..1361270 Replicon chromosome
Accession NZ_CP083445
Organism Klebsiella pneumoniae strain KP294

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LAV94_RS06775 Protein ID WP_002892050.1
Coordinates 1361052..1361270 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LAV94_RS06770 Protein ID WP_002892066.1
Coordinates 1360651..1361025 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAV94_RS06760 (1355803) 1355803..1356996 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LAV94_RS06765 (1357019) 1357019..1360165 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LAV94_RS06770 (1360651) 1360651..1361025 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LAV94_RS06775 (1361052) 1361052..1361270 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LAV94_RS06780 (1361429) 1361429..1361995 + 567 WP_004191639.1 maltose O-acetyltransferase -
LAV94_RS06785 (1361967) 1361967..1362107 - 141 WP_004147370.1 hypothetical protein -
LAV94_RS06790 (1362128) 1362128..1362598 + 471 WP_002892026.1 YlaC family protein -
LAV94_RS06795 (1362573) 1362573..1364024 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LAV94_RS06800 (1364125) 1364125..1364823 + 699 WP_002892021.1 GNAT family protein -
LAV94_RS06805 (1364820) 1364820..1364960 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LAV94_RS06810 (1364960) 1364960..1365223 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T216448 WP_002892050.1 NZ_CP083445:1361052-1361270 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T216448 NZ_CP113049:c2895857-2895396 [Staphylococcus aureus]
ATGAGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAAGCAGGAATTCTCTTCGAAGAAT
TAGCGCATAATAAACTTACATACGGTGATATAGCCGATTACTCGAATTTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCTGTACCGCTACGCGAAATTGTAGAAGCTTATAATTATGGCGTACGCAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACATTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT216448 WP_002892066.1 NZ_CP083445:1360651-1361025 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT216448 NZ_CP113049:c2896081-2895944 [Staphylococcus aureus]
ATGAAAACGGTAGCAGAAAAAATACCTATGGAGGATATAGCTGAGATTGCCAATGCATTGAAAGTTACCCCCAGAATATT
TACTATTAAAAAAATAGACAAACAGAAAACGAAGTACAACATCGTGCAGCTCATTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References