216447

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 1886396..1886876 Replicon chromosome
Accession NZ_CP083444
Organism Bartonella taylorii strain IBS296

Toxin (Protein)


Gene name pasB Uniprot ID C6ADL3
Locus tag LAJ60_RS08300 Protein ID WP_015856325.1
Coordinates 1886607..1886876 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID N6VJG4
Locus tag LAJ60_RS08295 Protein ID WP_007346764.1
Coordinates 1886396..1886623 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAJ60_RS08245 (LAJ60_08265) 1881726..1882058 + 333 WP_208433208.1 DUF5664 domain-containing protein -
LAJ60_RS08250 (LAJ60_08270) 1882048..1882203 + 156 WP_208433381.1 hypothetical protein -
LAJ60_RS08255 (LAJ60_08275) 1882193..1883368 + 1176 WP_252619494.1 DUF1376 domain-containing protein -
LAJ60_RS08260 (LAJ60_08280) 1883289..1883738 + 450 WP_252619496.1 hypothetical protein -
LAJ60_RS08265 (LAJ60_08285) 1883921..1884247 + 327 WP_208437829.1 hypothetical protein -
LAJ60_RS08270 (LAJ60_08290) 1884272..1884577 - 306 WP_078692249.1 BrnA antitoxin family protein -
LAJ60_RS08275 (LAJ60_08295) 1884555..1884854 - 300 WP_006925654.1 BrnT family toxin -
LAJ60_RS08280 (LAJ60_08300) 1885049..1885489 + 441 WP_252619498.1 single-stranded DNA-binding protein -
LAJ60_RS08285 (LAJ60_08305) 1885489..1885809 + 321 WP_252619500.1 hypothetical protein -
LAJ60_RS08290 (LAJ60_08310) 1885796..1886299 + 504 WP_252619502.1 hypothetical protein -
LAJ60_RS08295 (LAJ60_08315) 1886396..1886623 + 228 WP_007346764.1 DUF6290 family protein Antitoxin
LAJ60_RS08300 (LAJ60_08320) 1886607..1886876 + 270 WP_015856325.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LAJ60_RS08305 (LAJ60_08325) 1886906..1887355 - 450 WP_246786274.1 hypothetical protein -
LAJ60_RS08310 (LAJ60_08330) 1887427..1887912 - 486 WP_026500647.1 hypothetical protein -
LAJ60_RS08315 (LAJ60_08335) 1888223..1888537 + 315 WP_252619504.1 hypothetical protein -
LAJ60_RS08320 (LAJ60_08340) 1888518..1889843 + 1326 WP_252619506.1 phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1875318..1907239 31921


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-86)

Antitoxin

Protein of unknown function DUF6290

(2-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10448.42 Da        Isoelectric Point: 10.2009

>T216447 WP_015856325.1 NZ_CP083444:1886607-1886876 [Bartonella taylorii]
MAWTIRYEKKALSFLKKCDKKEARRIVDFLDQHVAPLEDVRVIGKPLKGQLSGLWRYRVGDYRILCELYDKELVVLVLAI
GHRKSIYKG

Download         Length: 270 bp

>T216447 NZ_CP113049:2867149-2867301 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8742.78 Da        Isoelectric Point: 4.8780

>AT216447 WP_007346764.1 NZ_CP083444:1886396-1886623 [Bartonella taylorii]
MTISIRLPSDLETRLNNLAAKTGRTKSFYLREIIERGIEEAEDYYLASQVRERVRRGEGTFYSSEEVRKELGLDD

Download         Length: 228 bp

>AT216447 NZ_CP113049:2866525-2867124 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAGCATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATTGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCATAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A336NC70

Antitoxin

Source ID Structure
AlphaFold DB N6VJG4

References