Detailed information of TA system TA216446

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PemK-MazE
• Location: 1049358..1049905
• Replicon: chromosome
• Accession: NZ_CP083444
• Organism: Bartonella taylorii strain IBS296

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: LAJ60_RS04680
• Protein ID: WP_252619311.1
• Coordinates: 1049358..1049681 (-)
• Length: 108 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: LAJ60_RS04685
• Protein ID: WP_252619313.1
• Coordinates: 1049681..1049905 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LAJ60_RS04645 (LAJ60_04655)	1044488..1044550	+	63	WP_234924827.1	hypothetical protein	-
LAJ60_RS04650 (LAJ60_04660)	1044547..1046679	+	2133	WP_252619306.1	phage tail tape measure protein	-
LAJ60_RS04655 (LAJ60_04665)	1046685..1047065	+	381	WP_078692227.1	phage tail protein	-
LAJ60_RS04660 (LAJ60_04670)	1047062..1047286	+	225	WP_078692228.1	tail protein X	-
LAJ60_RS04665 (LAJ60_04675)	1047283..1048596	+	1314	WP_252619309.1	contractile injection system protein, VgrG/Pvc8 family	-
LAJ60_RS04670 (LAJ60_04680)	1048684..1049004	-	321	WP_010705378.1	putative addiction module antidote protein	-
LAJ60_RS04675 (LAJ60_04685)	1048991..1049293	-	303	WP_252619860.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LAJ60_RS04680 (LAJ60_04690)	1049358..1049681	-	324	WP_252619311.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
LAJ60_RS04685 (LAJ60_04695)	1049681..1049905	-	225	WP_252619313.1	antitoxin MazE family protein	Antitoxin
LAJ60_RS04690 (LAJ60_04700)	1050048..1050710	+	663	WP_252619315.1	glycoside hydrolase family protein	-
LAJ60_RS04695 (LAJ60_04705)	1050707..1050934	+	228	WP_252619317.1	hypothetical protein	-
LAJ60_RS04700 (LAJ60_04710)	1050867..1051073	+	207	WP_081485985.1	hypothetical protein	-
LAJ60_RS04705 (LAJ60_04715)	1051066..1051287	+	222	WP_252619319.1	hypothetical protein	-
LAJ60_RS04715 (LAJ60_04725)	1051815..1053029	+	1215	WP_078691660.1	porin	-
LAJ60_RS04720 (LAJ60_04730)	1053805..1054749	-	945	WP_078691661.1	N-acetylmuramoyl-L-alanine amidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1041900..1054749	12849

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-102)

Antitoxin

• Antitoxin MazE-like (7-72)

Sequences

Toxin

Protein

• Length: 108 a.a.
• Molecular weight: 11735.95 Da
• Isoelectric Point: 10.0409

>T216446 WP_252619311.1 NZ_CP083444:c1049681-1049358 [Bartonella taylorii]
MRGSLVTIAIQGDFGKPRPALIIQANQFSEHTSMTVLPITSTLVDAPLLRITIQPDSKNGLQKPSQVMIDKIMTVRCEKV
SPAFGSIRADKMLEIERCLAVFLGIVK

Nucleotide

• Length: 324 bp

>T216446 NZ_CP113049:2714731-2715093 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8835.25 Da
• Isoelectric Point: 9.4438

>AT216446 WP_252619313.1 NZ_CP083444:c1049905-1049681 [Bartonella taylorii]
MGTMHVNERVQKHRNAQRKAGLRLMQIWVPDTRQPNFVEECRRQCRLVVKMDKKDASMQLFMDQSLMDVDGWTD

Nucleotide

• Length: 225 bp

>AT216446 NZ_CP113049:2714564-2714734 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA