Detailed information of TA system TA216444

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/upstrm_HI1419-DUF971
• Location: 615236..615809
• Replicon: chromosome
• Accession: NZ_CP083444
• Organism: Bartonella taylorii strain IBS296

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: LAJ60_RS02670
• Protein ID: WP_252619684.1
• Coordinates: 615236..615544 (+)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: LAJ60_RS02675
• Protein ID: WP_252619686.1
• Coordinates: 615525..615809 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LAJ60_RS02650 (LAJ60_02660)	610949..611782	+	834	WP_252619446.1	hypothetical protein	-
LAJ60_RS02655 (LAJ60_02665)	611869..612423	+	555	WP_252619444.1	hypothetical protein	-
LAJ60_RS02660 (LAJ60_02670)	612520..613299	+	780	WP_252619680.1	hypothetical protein	-
LAJ60_RS02665 (LAJ60_02675)	614636..615163	-	528	WP_252619682.1	hypothetical protein	-
LAJ60_RS02670 (LAJ60_02680)	615236..615544	+	309	WP_252619684.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LAJ60_RS02675 (LAJ60_02685)	615525..615809	+	285	WP_252619686.1	putative addiction module antidote protein	Antitoxin
LAJ60_RS02680 (LAJ60_02690)	615845..616225	-	381	WP_252619688.1	hypothetical protein	-
LAJ60_RS02685 (LAJ60_02695)	616237..616617	-	381	WP_252619690.1	hypothetical protein	-
LAJ60_RS02690 (LAJ60_02700)	616638..617765	-	1128	WP_252619692.1	N4-gp56 family major capsid protein	-
LAJ60_RS02695 (LAJ60_02705)	617858..618751	-	894	WP_252619694.1	hypothetical protein	-
LAJ60_RS02700 (LAJ60_02710)	618765..620774	-	2010	WP_252619696.1	portal protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	610949..637426	26477

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-91)

Antitoxin

• Uncharacterized protein HI1420 (10-92)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11855.77 Da
• Isoelectric Point: 9.8738

>T216444 WP_252619684.1 NZ_CP083444:615236-615544 [Bartonella taylorii]
MITIHKTTEFDTWLKKLNDKGVKAIILQRVIRLRQGLLGDVKFFNGIGELRIHYGAGYRIYFTQKGSDFILLLCGGDKST
QKRDIERALKLKEEYSDENYTI

Nucleotide

• Length: 309 bp

>T216444 NZ_CP113049:2635263-2635367 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10299.66 Da
• Isoelectric Point: 7.0117

>AT216444 WP_252619686.1 NZ_CP083444:615525-615809 [Bartonella taylorii]
MKTTPFKPEEYLETTEEQQIFLNEAFKTGDAAHIADALGIVARAQNMRALAKETNRERSGLYRSLSKTGDPKLSTLVAVL
SALNLQLSVQSSTS

Nucleotide

• Length: 285 bp

>AT216444 NZ_CP113049:c2635526-2635362 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT