Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4924244..4924760 Replicon chromosome
Accession NZ_CP083443
Organism Klebsiella pneumoniae strain KP1711R

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag K9870_RS23770 Protein ID WP_004178374.1
Coordinates 4924244..4924528 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K9870_RS23775 Protein ID WP_002886901.1
Coordinates 4924518..4924760 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9870_RS23745 (4919728) 4919728..4920036 - 309 WP_022631369.1 PTS sugar transporter subunit IIB -
K9870_RS23750 (4920121) 4920121..4920294 + 174 WP_032408826.1 hypothetical protein -
K9870_RS23755 (4920297) 4920297..4921040 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K9870_RS23760 (4921397) 4921397..4923535 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
K9870_RS23765 (4923776) 4923776..4924240 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K9870_RS23770 (4924244) 4924244..4924528 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K9870_RS23775 (4924518) 4924518..4924760 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K9870_RS23780 (4924838) 4924838..4926748 - 1911 WP_004178373.1 PRD domain-containing protein -
K9870_RS23785 (4926771) 4926771..4927925 - 1155 WP_004178372.1 lactonase family protein -
K9870_RS23790 (4927992) 4927992..4928732 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T216441 WP_004178374.1 NZ_CP083443:c4924528-4924244 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T216441 NZ_CP113049:1111384-1111572 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT216441 WP_002886901.1 NZ_CP083443:c4924760-4924518 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT216441 NZ_CP113049:1111095-1111355 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGTTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References