Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 733972..734498 Replicon chromosome
Accession NZ_CP083443
Organism Klebsiella pneumoniae strain KP1711R

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag K9870_RS03615 Protein ID WP_000323025.1
Coordinates 733972..734259 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag K9870_RS03620 Protein ID WP_000534858.1
Coordinates 734259..734498 (-) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9870_RS03580 (729018) 729018..729251 - 234 WP_004181905.1 hypothetical protein -
K9870_RS03585 (729330) 729330..729677 - 348 WP_004181904.1 hypothetical protein -
K9870_RS03590 (729833) 729833..730900 - 1068 WP_004181903.1 hypothetical protein -
K9870_RS03595 (731590) 731590..731967 + 378 WP_004181901.1 hypothetical protein -
K9870_RS03600 (732165) 732165..733139 - 975 WP_004181899.1 hypothetical protein -
K9870_RS26370 (733742) 733742..733900 - 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
K9870_RS03615 (733972) 733972..734259 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
K9870_RS03620 (734259) 734259..734498 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
K9870_RS03625 (734523) 734523..734627 + 105 Protein_711 protein YdfV -
K9870_RS03630 (734761) 734761..735060 - 300 WP_224146628.1 cation transporter dimerization domain-containing protein -
K9870_RS03635 (735250) 735250..736418 + 1169 WP_085929673.1 IS3-like element ISEc52 family transposase -
K9870_RS03640 (736479) 736479..737762 + 1284 WP_223819051.1 DEAD/DEAH box helicase -
K9870_RS03645 (738030) 738030..738644 - 615 WP_004026303.1 lytic transglycosylase domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element aac(3)-IId / blaSHV-187 fimA / fimI / fimC / fimD / fimD / fimF / fimG / rmpA / iutA / iucD / iucC / iucB / iucA 580689..808269 227580


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T216425 WP_000323025.1 NZ_CP083443:c734259-733972 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T216425 NZ_CP113044:c589061-588795 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT216425 WP_000534858.1 NZ_CP083443:c734498-734259 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT216425 NZ_CP113044:c589318-589061 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References