Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 6287738..6288257 Replicon chromosome
Accession NZ_CP083442
Organism Pseudomonas chlororaphis strain L5734

Toxin (Protein)


Gene name relE Uniprot ID A0A2N8AL54
Locus tag K9V45_RS28830 Protein ID WP_025804441.1
Coordinates 6287976..6288257 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1H3UB71
Locus tag K9V45_RS28825 Protein ID WP_009044432.1
Coordinates 6287738..6287986 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9V45_RS28805 (K9V45_28805) 6282781..6284550 - 1770 WP_226304059.1 hypothetical protein -
K9V45_RS28810 (K9V45_28810) 6284954..6285742 + 789 WP_226304060.1 hypothetical protein -
K9V45_RS28815 (K9V45_28815) 6285770..6286768 - 999 WP_102678122.1 bile acid:sodium symporter family protein -
K9V45_RS28820 (K9V45_28820) 6286853..6287641 + 789 WP_226304061.1 helix-turn-helix transcriptional regulator -
K9V45_RS28825 (K9V45_28825) 6287738..6287986 + 249 WP_009044432.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K9V45_RS28830 (K9V45_28830) 6287976..6288257 + 282 WP_025804441.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K9V45_RS28835 (K9V45_28835) 6288278..6288589 + 312 WP_226304062.1 hypothetical protein -
K9V45_RS28840 (K9V45_28840) 6288668..6290317 - 1650 WP_226304063.1 FMN-binding glutamate synthase family protein -
K9V45_RS28845 (K9V45_28845) 6290374..6290856 - 483 WP_009049637.1 acyl-CoA thioesterase -
K9V45_RS28850 (K9V45_28850) 6291201..6291506 + 306 WP_226304064.1 pyocin S6 family toxin immunity protein -
K9V45_RS28855 (K9V45_28855) 6292080..6292352 - 273 WP_226304065.1 hypothetical protein -
K9V45_RS28860 (K9V45_28860) 6292768..6293157 + 390 WP_025810081.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10791.60 Da        Isoelectric Point: 10.5816

>T216423 WP_025804441.1 NZ_CP083442:6287976-6288257 [Pseudomonas chlororaphis]
MTYELEFSEKAWKEWQKLGPTLKEQFKKKLQERLVNPHVPADRLSGLGNAYKIKLRTAGYRLVYRVVDEVLVVTVIAVGK
RERGSVYQQAGKR

Download         Length: 282 bp

>T216423 NZ_CP113044:c532213-531947 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8997.37 Da        Isoelectric Point: 4.4142

>AT216423 WP_009044432.1 NZ_CP083442:6287738-6287986 [Pseudomonas chlororaphis]
MTHVLLSNVVASISELKKNPMGTVAAGGGSSVAILNRNEPAFYCVPAKEYEAMMERLEDMELLALCRERENDPTIKVSLD
DL

Download         Length: 249 bp

>AT216423 NZ_CP113044:c532464-532213 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGTTATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N8AL54

Antitoxin

Source ID Structure
AlphaFold DB A0A1H3UB71

References