Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3209696..3210309 Replicon chromosome
Accession NZ_CP083442
Organism Pseudomonas chlororaphis strain L5734

Toxin (Protein)


Gene name hicA Uniprot ID A0A285EYZ4
Locus tag K9V45_RS14680 Protein ID WP_009041685.1
Coordinates 3210127..3210309 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag K9V45_RS14675 Protein ID WP_025808441.1
Coordinates 3209696..3210097 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9V45_RS14650 (K9V45_14650) 3205200..3206039 + 840 WP_226305527.1 taurine ABC transporter permease TauC -
K9V45_RS14655 (K9V45_14655) 3206285..3207124 + 840 WP_226305528.1 taurine dioxygenase -
K9V45_RS14660 (K9V45_14660) 3207264..3207509 + 246 WP_009046453.1 plasmid stabilization protein -
K9V45_RS14665 (K9V45_14665) 3207506..3207934 + 429 WP_025808439.1 type II toxin-antitoxin system VapC family toxin -
K9V45_RS14670 (K9V45_14670) 3208064..3209101 - 1038 WP_226305529.1 L-glyceraldehyde 3-phosphate reductase -
K9V45_RS14675 (K9V45_14675) 3209696..3210097 - 402 WP_025808441.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
K9V45_RS14680 (K9V45_14680) 3210127..3210309 - 183 WP_009041685.1 type II toxin-antitoxin system HicA family toxin Toxin
K9V45_RS14685 (K9V45_14685) 3210434..3211324 - 891 WP_226305530.1 LysR family transcriptional regulator -
K9V45_RS14690 (K9V45_14690) 3211455..3212195 + 741 WP_226305531.1 SDR family oxidoreductase -
K9V45_RS14695 (K9V45_14695) 3212252..3212740 + 489 WP_226305532.1 DoxX family protein -
K9V45_RS14700 (K9V45_14700) 3212793..3213050 + 258 WP_025808445.1 hypothetical protein -
K9V45_RS14705 (K9V45_14705) 3213172..3215136 - 1965 WP_226305631.1 choline transporter BetT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6933.08 Da        Isoelectric Point: 10.4588

>T216422 WP_009041685.1 NZ_CP083442:c3210309-3210127 [Pseudomonas chlororaphis]
MRSRELIRMIEEDGWYLIAVKGSHHQYKHLHKPGRVTIPHPDADLPRGTIHSILKQAGLK

Download         Length: 183 bp

>T216422 NZ_CP113044:c267456-267352 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14568.38 Da        Isoelectric Point: 4.9036

>AT216422 WP_025808441.1 NZ_CP083442:c3210097-3209696 [Pseudomonas chlororaphis]
MKFPVVLHKDADSGYGVIVPDVPGCFSAGHTAAQAFENVKEALSLHYEGLVADGEPLPQVHEVDVHIDNPDYAGGVWGVV
DFDITPYFGKAVRFNATLPEQLLERIDQTVKRDQRYRSRSGFLAAAALRELSA

Download         Length: 402 bp

>AT216422 NZ_CP113044:267258-267296 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285EYZ4

Antitoxin

Source ID Structure

References