Detailed information of TA system TA216418

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1214072..1214691
• Replicon: chromosome
• Accession: NZ_CP083442
• Organism: Pseudomonas chlororaphis strain L5734

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: K9V45_RS05440
• Protein ID: WP_053278351.1
• Coordinates: 1214072..1214254 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: K9V45_RS05445
• Protein ID: WP_226304886.1
• Coordinates: 1214290..1214691 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9V45_RS05430 (K9V45_05430)	1210411..1212591	-	2181	WP_226304884.1	hypothetical protein	-
K9V45_RS05435 (K9V45_05435)	1213428..1213709	+	282	WP_226304885.1	hypothetical protein	-
K9V45_RS05440 (K9V45_05440)	1214072..1214254	+	183	WP_053278351.1	type II toxin-antitoxin system HicA family toxin	Toxin
K9V45_RS05445 (K9V45_05445)	1214290..1214691	+	402	WP_226304886.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
K9V45_RS05450 (K9V45_05450)	1215268..1215985	-	718	Protein_1098	hypothetical protein	-
K9V45_RS05455 (K9V45_05455)	1216127..1216763	-	637	Protein_1099	response regulator transcription factor	-
K9V45_RS05460 (K9V45_05460)	1216760..1218649	-	1890	WP_226304887.1	PAS domain S-box protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6799.98 Da
• Isoelectric Point: 10.9678

>T216418 WP_053278351.1 NZ_CP083442:1214072-1214254 [Pseudomonas chlororaphis]
VQSRQLIKELEAAGWVLERVTGSHHLFKHPYRPETVPVPHPKKDLPRGTVRAIQKLAGLL

Nucleotide

• Length: 183 bp

>T216418 NZ_CP113042:c2911050-2910898 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14607.63 Da
• Isoelectric Point: 4.6017

>AT216418 WP_226304886.1 NZ_CP083442:1214290-1214691 [Pseudomonas chlororaphis]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAIEIAHVMLEELAREGQAIPLPSPIGTHRANPDFEGMGWGM
LDIDITLYLGKTEKVNVTLPGYVIQRIDRFVREHNIKSRSSFLADAAMEKLGR

Nucleotide

• Length: 402 bp

>AT216418 NZ_CP113042:c2911674-2911075 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA