Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 1197628..1198213 Replicon chromosome
Accession NZ_CP083442
Organism Pseudomonas chlororaphis strain L5734

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag K9V45_RS05375 Protein ID WP_226304876.1
Coordinates 1197628..1197921 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A3G7CJP2
Locus tag K9V45_RS05380 Protein ID WP_025804100.1
Coordinates 1197923..1198213 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9V45_RS05355 (K9V45_05355) 1192675..1193073 - 399 WP_016702749.1 carboxymuconolactone decarboxylase family protein -
K9V45_RS05360 (K9V45_05360) 1193274..1194517 - 1244 Protein_1080 M20/M25/M40 family metallo-hydrolase -
K9V45_RS05365 (K9V45_05365) 1194611..1195735 - 1125 WP_051519186.1 diguanylate cyclase -
K9V45_RS05370 (K9V45_05370) 1195998..1197392 + 1395 WP_226304875.1 VOC family protein -
K9V45_RS05375 (K9V45_05375) 1197628..1197921 + 294 WP_226304876.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K9V45_RS05380 (K9V45_05380) 1197923..1198213 + 291 WP_025804100.1 putative addiction module antidote protein Antitoxin
K9V45_RS05385 (K9V45_05385) 1198635..1199222 - 588 WP_226304877.1 hypothetical protein -
K9V45_RS05390 (K9V45_05390) 1199350..1200426 - 1077 WP_226304878.1 lipocalin-like domain-containing protein -
K9V45_RS05395 (K9V45_05395) 1200416..1202896 - 2481 WP_226304879.1 FtsX-like permease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-97)

Antitoxin

Uncharacterized protein HI1420

(9-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10812.50 Da        Isoelectric Point: 10.4234

>T216417 WP_226304876.1 NZ_CP083442:1197628-1197921 [Pseudomonas chlororaphis]
MEYEILQTTVFAQWHTRLRDLRARIAIARRIERASAGNLGDVKNLGGGLSEMRVNMGAGYRIYFTVRGNTLIVLLLGGDK
STQPADICQARSLAKEF

Download         Length: 294 bp

>T216417 NZ_CP113042:2853050-2853145 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10249.81 Da        Isoelectric Point: 8.0096

>AT216417 WP_025804100.1 NZ_CP083442:1197923-1198213 [Pseudomonas chlororaphis]
MSDTLVPFDIATLLDSDQAISEYLSQVLADGDTDELIRALGHVARARGMTQIAKATGQGRASLYKAFAPGAKPRFDTVVK
VMRALGLQLCTTVPRG

Download         Length: 291 bp

>AT216417 NZ_CP113042:c2853232-2853173 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3G7CJP2

References