Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2737315..2738091 Replicon chromosome
Accession NZ_CP083434
Organism Staphylococcus aureus strain DC.RB_015

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag LAE57_RS13325 Protein ID WP_000031108.1
Coordinates 2737939..2738091 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A6B1RP77
Locus tag LAE57_RS13320 Protein ID WP_001251218.1
Coordinates 2737315..2737914 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAE57_RS13300 (2733231) 2733231..2734688 + 1458 WP_000649908.1 ABC transporter permease subunit -
LAE57_RS13305 (2734681) 2734681..2735403 + 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
LAE57_RS13310 (2735554) 2735554..2736681 + 1128 WP_000379977.1 tRNA epoxyqueuosine(34) reductase QueG -
LAE57_RS13315 (2736686) 2736686..2737156 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
LAE57_RS13320 (2737315) 2737315..2737914 + 600 WP_001251218.1 glucosamine-6-phosphate isomerase Antitoxin
LAE57_RS13325 (2737939) 2737939..2738091 + 153 WP_000031108.1 SAS053 family protein Toxin
LAE57_RS13330 (2738754) 2738754..2739149 + 396 WP_057504578.1 hypothetical protein -
LAE57_RS13335 (2739345) 2739345..2740730 + 1386 WP_000116233.1 class II fumarate hydratase -
LAE57_RS13340 (2741195) 2741195..2742016 - 822 WP_000669384.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T216412 WP_000031108.1 NZ_CP083434:2737939-2738091 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T216412 NZ_CP113042:c267457-267353 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT216412 WP_001251218.1 NZ_CP083434:2737315-2737914 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFIVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT216412 NZ_CP113042:267240-267295 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A6B1RP77

References