Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | tsbAT/- |
Location | 2737315..2738091 | Replicon | chromosome |
Accession | NZ_CP083434 | ||
Organism | Staphylococcus aureus strain DC.RB_015 |
Toxin (Protein)
Gene name | tsbT | Uniprot ID | X5E2E6 |
Locus tag | LAE57_RS13325 | Protein ID | WP_000031108.1 |
Coordinates | 2737939..2738091 (+) | Length | 51 a.a. |
Antitoxin (Protein)
Gene name | tsbA | Uniprot ID | A0A6B1RP77 |
Locus tag | LAE57_RS13320 | Protein ID | WP_001251218.1 |
Coordinates | 2737315..2737914 (+) | Length | 200 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LAE57_RS13300 (2733231) | 2733231..2734688 | + | 1458 | WP_000649908.1 | ABC transporter permease subunit | - |
LAE57_RS13305 (2734681) | 2734681..2735403 | + | 723 | WP_000590809.1 | amino acid ABC transporter ATP-binding protein | - |
LAE57_RS13310 (2735554) | 2735554..2736681 | + | 1128 | WP_000379977.1 | tRNA epoxyqueuosine(34) reductase QueG | - |
LAE57_RS13315 (2736686) | 2736686..2737156 | + | 471 | WP_000181394.1 | tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL | - |
LAE57_RS13320 (2737315) | 2737315..2737914 | + | 600 | WP_001251218.1 | glucosamine-6-phosphate isomerase | Antitoxin |
LAE57_RS13325 (2737939) | 2737939..2738091 | + | 153 | WP_000031108.1 | SAS053 family protein | Toxin |
LAE57_RS13330 (2738754) | 2738754..2739149 | + | 396 | WP_057504578.1 | hypothetical protein | - |
LAE57_RS13335 (2739345) | 2739345..2740730 | + | 1386 | WP_000116233.1 | class II fumarate hydratase | - |
LAE57_RS13340 (2741195) | 2741195..2742016 | - | 822 | WP_000669384.1 | RluA family pseudouridine synthase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5936.28 Da Isoelectric Point: 3.8962
>T216412 WP_000031108.1 NZ_CP083434:2737939-2738091 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ
Download Length: 153 bp
>T216412 NZ_CP113042:c267457-267353 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA
Antitoxin
Download Length: 200 a.a. Molecular weight: 22357.50 Da Isoelectric Point: 5.1445
>AT216412 WP_001251218.1 NZ_CP083434:2737315-2737914 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFIVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFIVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA
Download Length: 600 bp
>AT216412 NZ_CP113042:267240-267295 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | X5E2E6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6B1RP77 |