Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TscAT/- |
| Location | 1015272..1015804 | Replicon | chromosome |
| Accession | NZ_CP083434 | ||
| Organism | Staphylococcus aureus strain DC.RB_015 | ||
Toxin (Protein)
| Gene name | TscT | Uniprot ID | Q93CD4 |
| Locus tag | LAE57_RS04830 | Protein ID | WP_001103942.1 |
| Coordinates | 1015272..1015592 (-) | Length | 107 a.a. |
Antitoxin (Protein)
| Gene name | TscA | Uniprot ID | - |
| Locus tag | LAE57_RS04835 | Protein ID | WP_001058486.1 |
| Coordinates | 1015595..1015804 (-) | Length | 70 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LAE57_RS04800 (1010423) | 1010423..1010764 | - | 342 | WP_001190615.1 | hypothetical protein | - |
| LAE57_RS04805 (1011281) | 1011281..1011922 | - | 642 | WP_001019764.1 | hypothetical protein | - |
| LAE57_RS04810 (1011919) | 1011919..1012203 | - | 285 | WP_000998181.1 | hypothetical protein | - |
| LAE57_RS04815 (1012205) | 1012205..1012567 | - | 363 | WP_001039168.1 | hypothetical protein | - |
| LAE57_RS04820 (1012853) | 1012853..1014322 | - | 1470 | WP_000390454.1 | virulence-associated E family protein | - |
| LAE57_RS04825 (1014339) | 1014339..1015208 | - | 870 | WP_001002732.1 | primase alpha helix C-terminal domain-containing protein | - |
| LAE57_RS04830 (1015272) | 1015272..1015592 | - | 321 | WP_001103942.1 | DUF1474 family protein | Toxin |
| LAE57_RS04835 (1015595) | 1015595..1015804 | - | 210 | WP_001058486.1 | hypothetical protein | Antitoxin |
| LAE57_RS04840 (1015797) | 1015797..1015943 | - | 147 | WP_000784875.1 | hypothetical protein | - |
| LAE57_RS04845 (1015955) | 1015955..1016227 | - | 273 | WP_000091731.1 | helix-turn-helix domain-containing protein | - |
| LAE57_RS04850 (1016220) | 1016220..1016483 | - | 264 | WP_000243851.1 | helix-turn-helix transcriptional regulator | - |
| LAE57_RS04855 (1016676) | 1016676..1017008 | + | 333 | WP_001260004.1 | helix-turn-helix transcriptional regulator | - |
| LAE57_RS04860 (1017020) | 1017020..1017478 | + | 459 | WP_000281657.1 | ImmA/IrrE family metallo-endopeptidase | - |
| LAE57_RS04865 (1017495) | 1017495..1017926 | + | 432 | WP_001228759.1 | hypothetical protein | - |
| LAE57_RS04870 (1017997) | 1017997..1018725 | + | 729 | WP_001033316.1 | staphylococcal enterotoxin type Q | - |
| LAE57_RS04875 (1018749) | 1018749..1019477 | + | 729 | WP_000733774.1 | staphylococcal enterotoxin type K | - |
| LAE57_RS04880 (1019566) | 1019566..1020786 | + | 1221 | WP_000266157.1 | site-specific integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | seb / selq / selk / vWbp | 1005472..1051282 | 45810 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12694.22 Da Isoelectric Point: 4.7419
>T216400 WP_001103942.1 NZ_CP083434:c1015592-1015272 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE
Download Length: 321 bp
>T216400 NZ_CP113039:c445111-444749 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG
Antitoxin
Download Length: 70 a.a. Molecular weight: 8252.31 Da Isoelectric Point: 4.3718
>AT216400 WP_001058486.1 NZ_CP083434:c1015804-1015595 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
Download Length: 210 bp
>AT216400 NZ_CP113039:c445278-445108 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|