Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4448311..4448906 Replicon chromosome
Accession NZ_CP083410
Organism Escherichia coli strain RP437

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag LAJ62_RS21570 Protein ID WP_000239577.1
Coordinates 4448556..4448906 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag LAJ62_RS21565 Protein ID WP_001223208.1
Coordinates 4448311..4448562 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAJ62_RS21555 (4443976) 4443976..4447755 + 3780 WP_000060911.1 autotransporter assembly complex protein TamB -
LAJ62_RS21560 (4447758) 4447758..4448099 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
LAJ62_RS21565 (4448311) 4448311..4448562 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
LAJ62_RS21570 (4448556) 4448556..4448906 + 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
LAJ62_RS21575 (4448986) 4448986..4449516 - 531 WP_000055075.1 inorganic diphosphatase -
LAJ62_RS21580 (4449826) 4449826..4450782 + 957 WP_000265913.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
LAJ62_RS21585 (4450922) 4450922..4452424 + 1503 WP_000205805.1 sugar ABC transporter ATP-binding protein -
LAJ62_RS21590 (4452438) 4452438..4453460 + 1023 WP_001313531.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T216392 WP_000239577.1 NZ_CP083410:4448556-4448906 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T216392 NZ_CP113037:1640652-1640903 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATTGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTAAGGGTTTACCTAATGCTATGCAAGATGCAC
TCAAAGAAGATATTGGTCTTGATGAAGCAGTAGGGATTATGACGGGGCAAGTGGTCTATAAATATGAGGAGGAGCAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT216392 WP_001223208.1 NZ_CP083410:4448311-4448562 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT216392 NZ_CP113037:1640893-1641066 [Staphylococcus aureus]
ATGAGTATTAGTGTAGGAGATAAAGTATATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCTGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References