Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4637437..4638053 Replicon chromosome
Accession NZ_CP083403
Organism Enterobacter bugandensis strain XL95

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag K9O83_RS22030 Protein ID WP_077266491.1
Coordinates 4637437..4637808 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A6G4MTK3
Locus tag K9O83_RS22035 Protein ID WP_015569912.1
Coordinates 4637811..4638053 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9O83_RS22015 (K9O83_21955) 4634937..4635839 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
K9O83_RS22020 (K9O83_21960) 4635836..4636471 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
K9O83_RS22025 (K9O83_21965) 4636468..4637397 + 930 WP_028014872.1 formate dehydrogenase accessory protein FdhE -
K9O83_RS22030 (K9O83_21970) 4637437..4637808 - 372 WP_077266491.1 type II toxin-antitoxin system VapC family toxin Toxin
K9O83_RS22035 (K9O83_21975) 4637811..4638053 - 243 WP_015569912.1 ribbon-helix-helix domain-containing protein Antitoxin
K9O83_RS22040 (K9O83_21980) 4638252..4639172 + 921 WP_049138052.1 alpha/beta hydrolase -
K9O83_RS22045 (K9O83_21985) 4639181..4640122 - 942 WP_047366783.1 fatty acid biosynthesis protein FabY -
K9O83_RS22050 (K9O83_21990) 4640167..4640604 - 438 WP_008501836.1 D-aminoacyl-tRNA deacylase -
K9O83_RS22055 (K9O83_21995) 4640601..4641482 - 882 WP_045260235.1 virulence factor BrkB family protein -
K9O83_RS22060 (K9O83_22000) 4641476..4642075 - 600 WP_224066098.1 glucose-1-phosphatase -
K9O83_RS22065 (K9O83_22005) 4642163..4642633 - 471 WP_028014878.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13723.85 Da        Isoelectric Point: 6.4882

>T216353 WP_077266491.1 NZ_CP083403:c4637808-4637437 [Enterobacter bugandensis]
MEHMAVFDTNILIDLFNNRVEAADAIEHTASHRAISLITWMEVMVGARRHGHEAKTAAVMGAFEIIDVSRDIAERSVLLR
EKHGMKLPDAIILATAQSRKCPLISRNTKDFAGIDEVLTPYQV

Download         Length: 372 bp

>T216353 NZ_CP113027:881113-881220 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9440.72 Da        Isoelectric Point: 4.4076

>AT216353 WP_015569912.1 NZ_CP083403:c4638053-4637811 [Enterobacter bugandensis]
MSVLAELDMGRILIDLSDDVIQRLDNLKQLRNQPRAELLREAIELYLDQQSSSVIRNALGLWGDRKEDGLEYERKLREEW

Download         Length: 243 bp

>AT216353 NZ_CP113027:c881297-881237 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A6G4MTK3

References