Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3863006..3863663 Replicon chromosome
Accession NZ_CP083403
Organism Enterobacter bugandensis strain XL95

Toxin (Protein)


Gene name cptA Uniprot ID A0A2J7SFN6
Locus tag K9O83_RS18285 Protein ID WP_028014322.1
Coordinates 3863006..3863416 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag K9O83_RS18290 Protein ID WP_010435322.1
Coordinates 3863397..3863663 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9O83_RS18265 (K9O83_18205) 3858999..3860732 - 1734 WP_041908356.1 single-stranded-DNA-specific exonuclease RecJ -
K9O83_RS18270 (K9O83_18210) 3860738..3861451 - 714 WP_028014319.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
K9O83_RS18275 (K9O83_18215) 3861480..3862376 - 897 WP_028014320.1 site-specific tyrosine recombinase XerD -
K9O83_RS18280 (K9O83_18220) 3862478..3862999 + 522 WP_041908355.1 flavodoxin FldB -
K9O83_RS18285 (K9O83_18225) 3863006..3863416 - 411 WP_028014322.1 protein YgfX Toxin
K9O83_RS18290 (K9O83_18230) 3863397..3863663 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
K9O83_RS18295 (K9O83_18235) 3863958..3864938 + 981 WP_224065969.1 tRNA-modifying protein YgfZ -
K9O83_RS18300 (K9O83_18240) 3865026..3865685 - 660 WP_023331242.1 hemolysin III family protein -
K9O83_RS18305 (K9O83_18245) 3865951..3866682 + 732 WP_028014325.1 MurR/RpiR family transcriptional regulator -
K9O83_RS18310 (K9O83_18250) 3866799..3868232 + 1434 WP_224065970.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16024.98 Da        Isoelectric Point: 11.2845

>T216352 WP_028014322.1 NZ_CP083403:c3863416-3863006 [Enterobacter bugandensis]
VVLWQSDLRVSWRSQWMSLLLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGVPWMLNAGMMLRLRKVGGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T216352 NZ_CP113018:2487998-2488186 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT216352 WP_010435322.1 NZ_CP083403:c3863663-3863397 [Enterobacter bugandensis]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT216352 NZ_CP113018:2487709-2487969 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J7SFN6

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References