Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1123853..1124473 Replicon chromosome
Accession NZ_CP083403
Organism Enterobacter bugandensis strain XL95

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag K9O83_RS05290 Protein ID WP_008499287.1
Coordinates 1123853..1124071 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A8E1RNX1
Locus tag K9O83_RS05295 Protein ID WP_028012188.1
Coordinates 1124099..1124473 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9O83_RS05260 (K9O83_05260) 1119864..1120124 + 261 WP_006176933.1 type B 50S ribosomal protein L31 -
K9O83_RS05265 (K9O83_05265) 1120127..1120267 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
K9O83_RS05270 (K9O83_05270) 1120264..1120974 - 711 WP_045259912.1 GNAT family protein -
K9O83_RS05275 (K9O83_05275) 1121076..1122536 + 1461 WP_224066343.1 PLP-dependent aminotransferase family protein -
K9O83_RS05280 (K9O83_05280) 1122508..1122975 - 468 WP_028012186.1 YlaC family protein -
K9O83_RS05285 (K9O83_05285) 1123092..1123643 - 552 WP_028012187.1 maltose O-acetyltransferase -
K9O83_RS05290 (K9O83_05290) 1123853..1124071 - 219 WP_008499287.1 HHA domain-containing protein Toxin
K9O83_RS05295 (K9O83_05295) 1124099..1124473 - 375 WP_028012188.1 Hha toxicity modulator TomB Antitoxin
K9O83_RS05300 (K9O83_05300) 1124983..1128129 - 3147 WP_047367620.1 multidrug efflux RND transporter permease subunit AcrB -
K9O83_RS05305 (K9O83_05305) 1128152..1129345 - 1194 WP_028012190.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T216341 WP_008499287.1 NZ_CP083403:c1124071-1123853 [Enterobacter bugandensis]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T216341 NZ_CP113018:735111-735218 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14511.30 Da        Isoelectric Point: 4.8886

>AT216341 WP_028012188.1 NZ_CP083403:c1124473-1124099 [Enterobacter bugandensis]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT216341 NZ_CP113018:c735295-735235 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure

References