Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 100248..100918 Replicon plasmid pT173a
Accession NZ_CP083375
Organism Ensifer canadensis strain T173

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J3R84_RS38140 Protein ID WP_203529527.1
Coordinates 100248..100652 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J3R84_RS38145 Protein ID WP_203529525.1
Coordinates 100649..100918 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3R84_RS38120 (J3R84_37845) 96169..97575 + 1407 WP_203529532.1 hypothetical protein -
J3R84_RS38125 (J3R84_37850) 97705..98211 + 507 WP_203529530.1 GNAT family N-acetyltransferase -
J3R84_RS38130 (J3R84_37855) 98353..98661 - 309 WP_037197787.1 helix-turn-helix transcriptional regulator -
J3R84_RS38135 (J3R84_37860) 98683..100005 - 1323 WP_203529529.1 HipA domain-containing protein -
J3R84_RS38140 (J3R84_37865) 100248..100652 - 405 WP_203529527.1 type II toxin-antitoxin system VapC family toxin Toxin
J3R84_RS38145 (J3R84_37870) 100649..100918 - 270 WP_203529525.1 antitoxin Antitoxin
J3R84_RS38150 (J3R84_37875) 101064..101309 - 246 WP_037221867.1 transcriptional regulator -
J3R84_RS38155 (J3R84_37880) 101434..101973 + 540 WP_203529523.1 hypothetical protein -
J3R84_RS38160 (J3R84_37885) 102170..103762 + 1593 WP_203529520.1 ABC transporter substrate-binding protein -
J3R84_RS38165 (J3R84_37890) 103769..104746 + 978 WP_203529519.1 ABC transporter permease -
J3R84_RS38170 (J3R84_37895) 104758..105633 + 876 WP_203529517.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - katB 1..195834 195834


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(18-55)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14228.36 Da        Isoelectric Point: 5.1889

>T216338 WP_203529527.1 NZ_CP083375:c100652-100248 [Ensifer canadensis]
MSKLYMLDTSIVSELVRNPHGAVARRIAEVGPDAVCVSIITAAELRYGSAKKGSAKLSAQIEAILGSIPVLPLDVPADTE
YGGIRAELEAGGKPIGPNDLFIAAHAYALEAVLVTANTGEFNRVRSLRVENWLE

Download         Length: 405 bp

>T216338 NZ_CP113016:c1765280-1765092 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10239.66 Da        Isoelectric Point: 5.1499

>AT216338 WP_203529525.1 NZ_CP083375:c100918-100649 [Ensifer canadensis]
MPHLRNHESTPAREAKLFRNNKSQAVRIPADFEFSGDRVMIHREGDRLIIEPVRRKNLLDVLASLEPLGPDDQFPDIDDT
LLPVKEIDL

Download         Length: 270 bp

>AT216338 NZ_CP113016:c1765569-1765309 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTATATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References