Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 816540..817180 Replicon plasmid pT173d
Accession NZ_CP083374
Organism Ensifer canadensis strain T173

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J3R84_RS37210 Protein ID WP_203528566.1
Coordinates 816794..817180 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J3R84_RS37205 Protein ID WP_203528564.1
Coordinates 816540..816794 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3R84_RS37170 (J3R84_36900) 811724..812824 + 1101 WP_203528558.1 hypothetical protein -
J3R84_RS37175 (J3R84_36905) 812854..813360 - 507 Protein_728 helix-turn-helix domain-containing protein -
J3R84_RS37180 (J3R84_36910) 814023..814265 + 243 WP_057210673.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
J3R84_RS37185 (J3R84_36915) 814262..814681 + 420 WP_057210669.1 type II toxin-antitoxin system VapC family toxin -
J3R84_RS37190 (J3R84_36920) 814671..815831 + 1161 WP_203528560.1 site-specific integrase -
J3R84_RS37195 (J3R84_36925) 815939..816145 - 207 WP_203528562.1 cold-shock protein -
J3R84_RS37200 (J3R84_36930) 816246..816428 - 183 Protein_733 replication initiation protein RepC -
J3R84_RS37205 (J3R84_36935) 816540..816794 + 255 WP_203528564.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J3R84_RS37210 (J3R84_36940) 816794..817180 + 387 WP_203528566.1 type II toxin-antitoxin system VapC family toxin Toxin
J3R84_RS37215 (J3R84_36945) 817770..818738 - 969 WP_057213810.1 plasmid partitioning protein RepB -
J3R84_RS37220 (J3R84_36950) 818791..820014 - 1224 WP_203528568.1 plasmid partitioning protein RepA -
J3R84_RS37225 (J3R84_36955) 820754..821413 + 660 WP_057213816.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katB 1..946878 946878


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-83)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14003.82 Da        Isoelectric Point: 4.3961

>T216337 WP_203528566.1 NZ_CP083374:816794-817180 [Ensifer canadensis]
MVIDTSAIVAIAFNEPDAETYEQKVVDAPRRFISAATILELSIVIEARLGEAGAAELDLWLYKAGVEVVAVDAEQIAIAR
RAWRNFGKGRHPASLNFGDCFSYALAKSRNEPLLFNGDDFSRTDIEAA

Download         Length: 387 bp

>T216337 NZ_CP113016:c549985-549719 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAAATAAAACATCCTTATTTAAAGAAGAC
ATTTATAGAAATTGTTGAGACTTTAAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9403.83 Da        Isoelectric Point: 9.8590

>AT216337 WP_203528564.1 NZ_CP083374:816540-816794 [Ensifer canadensis]
MALSIKDLETERLAKALAEKTGETITMATRRALEERLRRLANAGNREVLLEELAASRKRWAKLPVLDKRSAGEILGYDEN
GLPN

Download         Length: 255 bp

>AT216337 NZ_CP113016:c550242-549985 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References