216336

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 733098..733678 Replicon plasmid pT173d
Accession NZ_CP083374
Organism Ensifer canadensis strain T173

Toxin (Protein)


Gene name vapC Uniprot ID A0A2T3CYN2
Locus tag J3R84_RS36780 Protein ID WP_057216466.1
Coordinates 733295..733678 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2T3CYK8
Locus tag J3R84_RS36775 Protein ID WP_057216469.1
Coordinates 733098..733298 (+) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3R84_RS36755 (J3R84_36505) 728806..729108 - 303 WP_057206768.1 DUF2147 domain-containing protein -
J3R84_RS36760 (J3R84_36510) 729336..729602 + 267 WP_057206766.1 hypothetical protein -
J3R84_RS36765 (J3R84_36515) 729657..730673 + 1017 WP_203528509.1 DUF4105 domain-containing protein -
J3R84_RS36770 (J3R84_36520) 731086..732894 + 1809 WP_057216472.1 hypothetical protein -
J3R84_RS36775 (J3R84_36525) 733098..733298 + 201 WP_057216469.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
J3R84_RS36780 (J3R84_36530) 733295..733678 + 384 WP_057216466.1 type II toxin-antitoxin system VapC family toxin Toxin
J3R84_RS36785 (J3R84_36535) 733903..735666 - 1764 WP_203528511.1 adenylate/guanylate cyclase domain-containing protein -
J3R84_RS36790 (J3R84_36540) 735979..736160 - 182 Protein_651 IS6 family transposase -
J3R84_RS36795 (J3R84_36545) 736274..736786 + 513 WP_057216459.1 hypothetical protein -
J3R84_RS36800 (J3R84_36550) 737002..737604 - 603 WP_203528513.1 TetR/AcrR family transcriptional regulator -
J3R84_RS36805 (J3R84_36555) 737910..738131 + 222 WP_203528515.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katB 1..946878 946878


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14277.44 Da        Isoelectric Point: 6.3753

>T216336 WP_057216466.1 NZ_CP083374:733295-733678 [Ensifer canadensis]
VILADTSIWIDHFRHVDIELRRIIEDDGLLCHPAVIGELALGRLRDRGSVIPFLAAQREAFVATHDEVMTMIDRHDIFSM
GIGYTEAHLLASVLLDQRAALWTRDKRLRAAAEKMGASLHTPVDARN

Download         Length: 384 bp

>T216336 NZ_CP113016:c493030-492764 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7171.29 Da        Isoelectric Point: 10.9487

>AT216336 WP_057216469.1 NZ_CP083374:733098-733298 [Ensifer canadensis]
MRSTIDLDDALMERARSLTGTKEIAALVRQALETFVRVESGKRLIALGGTMPDAEAAPRRRSTAAK

Download         Length: 201 bp

>AT216336 NZ_CP113016:c493281-493030 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T3CYN2

Antitoxin

Source ID Structure
AlphaFold DB A0A2T3CYK8

References