Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-StbC |
| Location | 297312..297982 | Replicon | plasmid pT173c |
| Accession | NZ_CP083373 | ||
| Organism | Ensifer canadensis strain T173 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | J3R84_RS31055 | Protein ID | WP_203529914.1 |
| Coordinates | 297563..297982 (+) | Length | 140 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | J3R84_RS31050 | Protein ID | WP_057220453.1 |
| Coordinates | 297312..297566 (+) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J3R84_RS31040 (J3R84_30860) | 292989..293399 | + | 411 | WP_057215867.1 | Ohr family peroxiredoxin | - |
| J3R84_RS31045 (J3R84_30865) | 293492..296338 | + | 2847 | WP_057220451.1 | winged helix-turn-helix domain-containing protein | - |
| J3R84_RS31050 (J3R84_30870) | 297312..297566 | + | 255 | WP_057220453.1 | hypothetical protein | Antitoxin |
| J3R84_RS31055 (J3R84_30875) | 297563..297982 | + | 420 | WP_203529914.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| J3R84_RS31060 (J3R84_30880) | 298116..298859 | - | 744 | WP_057210789.1 | 3-keto-5-aminohexanoate cleavage protein | - |
| J3R84_RS31065 | 299076..299521 | + | 446 | Protein_303 | hypothetical protein | - |
| J3R84_RS31070 (J3R84_30890) | 299548..299844 | - | 297 | WP_203530171.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| J3R84_RS31075 (J3R84_30895) | 299841..300107 | - | 267 | WP_203530172.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| J3R84_RS31080 (J3R84_30900) | 300501..300779 | - | 279 | WP_203530173.1 | hypothetical protein | - |
| J3R84_RS31085 (J3R84_30905) | 301060..302232 | - | 1173 | WP_203530174.1 | Fic family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | htpB | 1..782207 | 782207 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 140 a.a. Molecular weight: 14767.80 Da Isoelectric Point: 4.5127
>T216333 WP_203529914.1 NZ_CP083373:297563-297982 [Ensifer canadensis]
MIVLDTNVVSEAMKPAPDLAIRNWLNDQVAETLYLSSVTLAELLFGIAALPEGRRKKALADTLDGLLELFDDRVLSFDTA
AARHYADLAATARAGGEGFPAPNGYIAAIAASKGFTIATRDTSPFEAAGVPVVNPWNHL
MIVLDTNVVSEAMKPAPDLAIRNWLNDQVAETLYLSSVTLAELLFGIAALPEGRRKKALADTLDGLLELFDDRVLSFDTA
AARHYADLAATARAGGEGFPAPNGYIAAIAASKGFTIATRDTSPFEAAGVPVVNPWNHL
Download Length: 420 bp
>T216333 NZ_CP113015:c3022015-3021911 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9580.93 Da Isoelectric Point: 5.7485
>AT216333 WP_057220453.1 NZ_CP083373:297312-297566 [Ensifer canadensis]
MAILTVRNVPDEVHRALRVRAALHGRSTEAEVREILERAVKPEQRVRIGDALAELSGRLGLTNDDFEVFDQMREKAPAEP
MRFE
MAILTVRNVPDEVHRALRVRAALHGRSTEAEVREILERAVKPEQRVRIGDALAELSGRLGLTNDDFEVFDQMREKAPAEP
MRFE
Download Length: 255 bp
>AT216333 NZ_CP113015:3021798-3021853 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|