Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 22438..22934 Replicon plasmid pT173e
Accession NZ_CP083371
Organism Ensifer canadensis strain T173

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag J3R84_RS19750 Protein ID WP_203528708.1
Coordinates 22548..22934 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag J3R84_RS19745 Protein ID WP_272502211.1
Coordinates 22438..22551 (+) Length 38 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
J3R84_RS19710 (J3R84_19670) 18666..19379 + 714 WP_203528698.1 DNA helicase -
J3R84_RS19715 (J3R84_19675) 19558..20046 - 489 WP_057217847.1 dihydrofolate reductase -
J3R84_RS19720 20080..20247 - 168 Protein_19 GNAT family protein -
J3R84_RS19725 (J3R84_19680) 20245..20973 + 729 Protein_20 site-specific integrase -
J3R84_RS19730 (J3R84_19685) 21193..21711 - 519 WP_082555684.1 RES family NAD+ phosphorylase -
J3R84_RS19735 (J3R84_19690) 21708..22097 - 390 WP_025429740.1 DUF2384 domain-containing protein -
J3R84_RS19740 (J3R84_19695) 22232..22396 - 165 Protein_23 replication initiation protein RepC -
J3R84_RS19745 (J3R84_19700) 22438..22551 + 114 WP_272502211.1 hypothetical protein Antitoxin
J3R84_RS19750 (J3R84_19705) 22548..22934 + 387 WP_203528708.1 type II toxin-antitoxin system VapC family toxin Toxin
J3R84_RS19755 (J3R84_19710) 23008..23472 - 465 WP_025429738.1 Lrp/AsnC ligand binding domain-containing protein -
J3R84_RS19760 (J3R84_19715) 23632..24645 + 1014 WP_113567066.1 1-aminocyclopropane-1-carboxylate deaminase -
J3R84_RS19765 (J3R84_19720) 24736..25419 - 684 WP_225968552.1 aspartate/glutamate racemase family protein -
J3R84_RS19770 (J3R84_19725) 25515..26222 - 708 WP_203528696.1 DUF421 domain-containing protein -
J3R84_RS19775 (J3R84_19730) 26427..26627 + 201 WP_107027860.1 CsbD family protein -
J3R84_RS19780 (J3R84_19735) 26801..26968 + 168 WP_225906387.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - fcl / gmd 1..1913930 1913930


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14035.84 Da        Isoelectric Point: 4.3961

>T216327 WP_203528708.1 NZ_CP083371:22548-22934 [Ensifer canadensis]
MMVDTSAIVAIAFNEPDAETYEQKVVDAPRRFISAATILELSIVIEARLGEAGAAELDLWPYKASVEVVAVDAEQIAIAR
RAWRNFGKGRHPASLNFGDCFSYALAKSRNEPLLFNGDDFSRTDIEAA

Download         Length: 387 bp

>T216327 NZ_CP113015:2614765-2614860 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 38 a.a.        Molecular weight: 4180.77 Da        Isoelectric Point: 4.8283

>AT216327 WP_272502211.1 NZ_CP083371:22438-22551 [Ensifer canadensis]
VLLEELAASRKRWAKLPVLDKRSADEILGYDENGLPN

Download         Length: 114 bp

>AT216327 NZ_CP113015:c2614947-2614888 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References