Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 111248..112164 Replicon plasmid p1
Accession NZ_CP083367
Organism Pseudomonas aeruginosa strain PS1793

Toxin (Protein)


Gene name slvT Uniprot ID A0A2L1KI32
Locus tag FLI66_RS32960 Protein ID WP_019437783.1
Coordinates 111640..112164 (+) Length 175 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A2L1KH13
Locus tag FLI66_RS32955 Protein ID WP_019437782.1
Coordinates 111248..111643 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FLI66_RS32945 (FLI66_32900) 107169..107468 - 300 WP_136342214.1 hypothetical protein -
FLI66_RS32950 (FLI66_32905) 108780..110663 + 1884 WP_100247856.1 helicase -
FLI66_RS32955 (FLI66_32910) 111248..111643 + 396 WP_019437782.1 hypothetical protein Antitoxin
FLI66_RS32960 (FLI66_32915) 111640..112164 + 525 WP_019437783.1 RES family NAD+ phosphorylase Toxin
FLI66_RS32965 (FLI66_32920) 112210..113460 - 1251 WP_019437784.1 TerD family protein -
FLI66_RS32970 (FLI66_32925) 113794..114789 - 996 WP_079744282.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
FLI66_RS32975 (FLI66_32930) 115164..115355 + 192 WP_019437785.1 hypothetical protein -
FLI66_RS32980 (FLI66_32935) 115775..116920 - 1146 WP_019437787.1 glycerate kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid ant(2'')-Ia / blaOXA-14 / aadA10 / qacE / sul1 - 1..318215 318215


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(10-167)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19052.57 Da        Isoelectric Point: 4.5535

>T216323 WP_019437783.1 NZ_CP083367:111640-112164 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQASAFLPPGLLISYSLSLDRVI
DFTGGYNDTWAPIWQDFFCDWRKIRFNDGVEPPSWIIGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP

Download         Length: 525 bp

>T216323 NZ_CP113015:c296228-295962 [Staphylococcus aureus]
ATGAGTAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14753.87 Da        Isoelectric Point: 7.2048

>AT216323 WP_019437782.1 NZ_CP083367:111248-111643 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFGYKTAEEVVSEGKTEQLIAFLQSWEAGAQG

Download         Length: 396 bp

>AT216323 NZ_CP113015:c296485-296228 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L1KI32

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1KH13

References