Detailed information of TA system TA216317

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicB(antitoxin)
• Location: 2831385..2832036
• Replicon: chromosome
• Accession: NZ_CP083366
• Organism: Pseudomonas aeruginosa strain PS1793

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: FLI66_RS13715
• Protein ID: WP_019486655.1
• Coordinates: 2831857..2832036 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: FLI66_RS13710
• Protein ID: WP_019486656.1
• Coordinates: 2831385..2831816 (-)
• Length: 144 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FLI66_RS13670 (FLI66_13660)	2826697..2827566	-	870	WP_224396981.1	S24 family peptidase	-
FLI66_RS13675 (FLI66_13665)	2827475..2827678	+	204	WP_031692832.1	YdaS family helix-turn-helix protein	-
FLI66_RS13680 (FLI66_13670)	2827681..2827995	+	315	WP_019396727.1	CII family transcriptional regulator	-
FLI66_RS13685 (FLI66_13675)	2827996..2829009	+	1014	WP_019486661.1	DnaT-like ssDNA-binding domain-containing protein	-
FLI66_RS13690 (FLI66_13680)	2828951..2829547	+	597	WP_063869743.1	hypothetical protein	-
FLI66_RS13695 (FLI66_13685)	2829540..2829842	+	303	WP_019486659.1	hypothetical protein	-
FLI66_RS13700 (FLI66_13690)	2829839..2830285	+	447	WP_019486658.1	RusA family crossover junction endodeoxyribonuclease	-
FLI66_RS13705 (FLI66_13695)	2830408..2831295	+	888	WP_019486657.1	hypothetical protein	-
FLI66_RS13710 (FLI66_13700)	2831385..2831816	-	432	WP_019486656.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FLI66_RS13715 (FLI66_13705)	2831857..2832036	-	180	WP_019486655.1	type II toxin-antitoxin system HicA family toxin	Toxin
FLI66_RS13720 (FLI66_13710)	2832125..2832340	+	216	WP_019486654.1	hypothetical protein	-
FLI66_RS13725 (FLI66_13715)	2832483..2832872	+	390	WP_019486653.1	putative holin	-
FLI66_RS13730 (FLI66_13720)	2832865..2833149	+	285	WP_019486652.1	phage holin family protein	-
FLI66_RS13735 (FLI66_13725)	2833149..2833661	+	513	WP_019486651.1	glycoside hydrolase family 104 protein	-
FLI66_RS13740 (FLI66_13730)	2833658..2833849	+	192	WP_019486650.1	hypothetical protein	-
FLI66_RS13745 (FLI66_13735)	2833839..2834219	+	381	WP_019486649.1	hypothetical protein	-
FLI66_RS13750 (FLI66_13740)	2834248..2834478	-	231	WP_019486648.1	hypothetical protein	-
FLI66_RS13755 (FLI66_13745)	2834586..2835167	+	582	WP_019486647.1	hypothetical protein	-
FLI66_RS13760 (FLI66_13750)	2835172..2836830	+	1659	WP_198128982.1	terminase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2820260..2859386	39126

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (11-78)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6605.65 Da
• Isoelectric Point: 11.1475

>T216317 WP_019486655.1 NZ_CP083366:c2832036-2831857 [Pseudomonas aeruginosa]
MKFSEFRRWLRAQGVTFEAGKGSHFKVTAPNGKTTTFADHGAKEMPEPTRKAIIKQLGL

Nucleotide

• Length: 180 bp

>T216317 NZ_CP113009:c1979805-1979701 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Protein

• Length: 144 a.a.
• Molecular weight: 15862.17 Da
• Isoelectric Point: 4.7692

>AT216317 WP_019486656.1 NZ_CP083366:c2831816-2831385 [Pseudomonas aeruginosa]
MYNFAIRFEQDDSAPGVAVFCRDLPELNSYGNTVEHALGEAVDAIETTLSLYVDQRRPIPAASAPEPEEHVVHLPAVTVA
KIALWNEMMRRDMRKADLCRALGVAQVQVDRLVDFLHTSKMEQLESALGVLGLRLFVSVQQAA

Nucleotide

• Length: 432 bp

>AT216317 NZ_CP113009:1979588-1979643 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG