Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 2751802..2752844 | Replicon | chromosome |
| Accession | NZ_CP083366 | ||
| Organism | Pseudomonas aeruginosa strain PS1793 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | FLI66_RS13255 | Protein ID | WP_003153636.1 |
| Coordinates | 2752269..2752844 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | I3TV68 |
| Locus tag | FLI66_RS13250 | Protein ID | WP_003050245.1 |
| Coordinates | 2751802..2752272 (+) | Length | 157 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FLI66_RS13215 (FLI66_13205) | 2747194..2748612 | - | 1419 | WP_006226029.1 | TIGR03752 family integrating conjugative element protein | - |
| FLI66_RS13220 (FLI66_13210) | 2748602..2749513 | - | 912 | WP_006226028.1 | TIGR03749 family integrating conjugative element protein | - |
| FLI66_RS13225 (FLI66_13215) | 2749510..2750202 | - | 693 | WP_003090182.1 | TIGR03746 family integrating conjugative element protein | - |
| FLI66_RS13230 (FLI66_13220) | 2750199..2750597 | - | 399 | WP_003050133.1 | TIGR03750 family conjugal transfer protein | - |
| FLI66_RS13235 (FLI66_13225) | 2750609..2750968 | - | 360 | WP_003090173.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| FLI66_RS13240 (FLI66_13230) | 2750985..2751218 | - | 234 | WP_003090170.1 | TIGR03758 family integrating conjugative element protein | - |
| FLI66_RS13245 (FLI66_13235) | 2751215..2751598 | - | 384 | WP_003090167.1 | RAQPRD family integrative conjugative element protein | - |
| FLI66_RS13250 (FLI66_13240) | 2751802..2752272 | + | 471 | WP_003050245.1 | helix-turn-helix domain-containing protein | Antitoxin |
| FLI66_RS13255 (FLI66_13245) | 2752269..2752844 | + | 576 | WP_003153636.1 | PIN domain-containing protein | Toxin |
| FLI66_RS13260 (FLI66_13250) | 2752862..2753776 | + | 915 | WP_016852809.1 | AAA family ATPase | - |
| FLI66_RS13265 (FLI66_13255) | 2753773..2754243 | + | 471 | WP_003090160.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap8 | - |
| FLI66_RS13270 (FLI66_13260) | 2754240..2754740 | + | 501 | WP_003090159.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap7 | - |
| FLI66_RS13275 (FLI66_13265) | 2754740..2755642 | + | 903 | WP_003090158.1 | CBASS oligonucleotide cyclase | - |
| FLI66_RS13280 (FLI66_13270) | 2755681..2756406 | + | 726 | WP_003050273.1 | CBASS effector endonuclease NucC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 2677237..2801703 | 124466 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21629.78 Da Isoelectric Point: 5.9995
>T216316 WP_003153636.1 NZ_CP083366:2752269-2752844 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
Download Length: 576 bp
>T216316 NZ_CP113009:c1922441-1922232 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG
Antitoxin
Download Length: 157 a.a. Molecular weight: 17245.62 Da Isoelectric Point: 6.3803
>AT216316 WP_003050245.1 NZ_CP083366:2751802-2752272 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
Download Length: 471 bp
>AT216316 NZ_CP113009:c1922746-1922453 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|