Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RelE(toxin) |
| Location | 2150448..2151007 | Replicon | chromosome |
| Accession | NZ_CP083361 | ||
| Organism | Vibrio parahaemolyticus strain 20-082E4 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | K9N54_RS10475 | Protein ID | WP_025793444.1 |
| Coordinates | 2150729..2151007 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U2ZGZ5 |
| Locus tag | K9N54_RS10470 | Protein ID | WP_005497249.1 |
| Coordinates | 2150448..2150732 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K9N54_RS10425 (K9N54_10315) | 2145461..2145538 | - | 78 | WP_080277538.1 | DUF3265 domain-containing protein | - |
| K9N54_RS10430 (K9N54_10320) | 2145567..2146304 | - | 738 | WP_025793449.1 | phospholipase D-like domain-containing protein | - |
| K9N54_RS10435 (K9N54_10325) | 2146422..2147024 | - | 603 | WP_033904997.1 | hypothetical protein | - |
| K9N54_RS10440 (K9N54_10330) | 2147202..2147468 | - | 267 | WP_025793447.1 | barstar family protein | - |
| K9N54_RS10445 (K9N54_10335) | 2147510..2147602 | - | 93 | WP_080261757.1 | DUF3265 domain-containing protein | - |
| K9N54_RS10450 (K9N54_10340) | 2147676..2147978 | + | 303 | WP_025793446.1 | hypothetical protein | - |
| K9N54_RS10455 (K9N54_10345) | 2148127..2148474 | - | 348 | WP_025793445.1 | DUF6404 family protein | - |
| K9N54_RS10460 (K9N54_10350) | 2148567..2148656 | - | 90 | WP_077281693.1 | DUF3265 domain-containing protein | - |
| K9N54_RS10465 (K9N54_10355) | 2148690..2149058 | - | 369 | WP_224067034.1 | GFA family protein | - |
| K9N54_RS10470 (K9N54_10360) | 2150448..2150732 | + | 285 | WP_005497249.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| K9N54_RS10475 (K9N54_10365) | 2150729..2151007 | + | 279 | WP_025793444.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| K9N54_RS10480 (K9N54_10370) | 2151166..2151468 | - | 303 | WP_025548916.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| K9N54_RS10485 (K9N54_10375) | 2151456..2151713 | - | 258 | WP_005448240.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| K9N54_RS10490 (K9N54_10380) | 2151795..2151926 | - | 132 | WP_080277536.1 | DUF3265 domain-containing protein | - |
| K9N54_RS10495 (K9N54_10385) | 2153023..2153115 | - | 93 | WP_140050476.1 | DUF3265 domain-containing protein | - |
| K9N54_RS10500 (K9N54_10390) | 2153602..2153967 | - | 366 | WP_025793443.1 | hypothetical protein | - |
| K9N54_RS10505 (K9N54_10395) | 2154051..2154170 | - | 120 | WP_080277534.1 | DUF3265 domain-containing protein | - |
| K9N54_RS10510 (K9N54_10400) | 2154157..2154531 | - | 375 | WP_025793442.1 | hypothetical protein | - |
| K9N54_RS10515 (K9N54_10405) | 2154565..2154657 | - | 93 | WP_080277533.1 | DUF3265 domain-containing protein | - |
| K9N54_RS10520 (K9N54_10410) | 2154678..2155340 | - | 663 | WP_025793441.1 | hypothetical protein | - |
| K9N54_RS10525 (K9N54_10415) | 2155349..2155489 | - | 141 | WP_148299773.1 | DUF3265 domain-containing protein | - |
| K9N54_RS10530 (K9N54_10420) | 2155486..2155857 | - | 372 | WP_025793440.1 | RidA family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2041179..2166543 | 125364 | |
| - | inside | Integron | - | - | 2090758..2165418 | 74660 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10930.57 Da Isoelectric Point: 4.3697
>T216310 WP_025793444.1 NZ_CP083361:2150729-2151007 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPEAADKTDDIIEAKVENLLEQPHMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRIM
RVLHQKQKFPTD
MILWEEESLNDREKIFEFLYDFNPEAADKTDDIIEAKVENLLEQPHMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRIM
RVLHQKQKFPTD
Download Length: 279 bp
>T216310 NZ_CP113009:576622-576915 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAAGTGTACTTAAAAGAGTTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCGTCACTTCAAGCCGATCAAAGCGAAAGTAACGCATAG
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAAGTGTACTTAAAAGAGTTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCGTCACTTCAAGCCGATCAAAGCGAAAGTAACGCATAG
Antitoxin
Download Length: 95 a.a. Molecular weight: 10913.25 Da Isoelectric Point: 9.1865
>AT216310 WP_005497249.1 NZ_CP083361:2150448-2150732 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLADQQRKTLSHDAWLTEQVNLAFEKFDSGKATFVDHESAKSR
MAERKAKIRNRGKL
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLADQQRKTLSHDAWLTEQVNLAFEKFDSGKATFVDHESAKSR
MAERKAKIRNRGKL
Download Length: 285 bp
>AT216310 NZ_CP113009:576410-576619 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|