Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-YefM |
| Location | 2097188..2097733 | Replicon | chromosome |
| Accession | NZ_CP083361 | ||
| Organism | Vibrio parahaemolyticus strain 20-082E4 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | K9N54_RS09930 | Protein ID | WP_025793418.1 |
| Coordinates | 2097437..2097733 (+) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | - |
| Locus tag | K9N54_RS09925 | Protein ID | WP_023585842.1 |
| Coordinates | 2097188..2097430 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K9N54_RS09875 (K9N54_09830) | 2092860..2092952 | - | 93 | WP_005494856.1 | DUF3265 domain-containing protein | - |
| K9N54_RS09880 (K9N54_09835) | 2092967..2093518 | - | 552 | WP_223848446.1 | hypothetical protein | - |
| K9N54_RS09885 (K9N54_09840) | 2093648..2094052 | - | 405 | WP_025793460.1 | hypothetical protein | - |
| K9N54_RS09890 | 2094202..2094441 | - | 240 | Protein_1921 | hypothetical protein | - |
| K9N54_RS09895 (K9N54_09845) | 2094576..2094668 | - | 93 | WP_080277545.1 | DUF3265 domain-containing protein | - |
| K9N54_RS09900 (K9N54_09850) | 2094683..2095069 | - | 387 | WP_025793461.1 | hypothetical protein | - |
| K9N54_RS09905 (K9N54_09855) | 2095062..2095916 | - | 855 | WP_025793462.1 | AAA family ATPase | - |
| K9N54_RS09910 (K9N54_09860) | 2096010..2096102 | - | 93 | WP_005494820.1 | DUF3265 domain-containing protein | - |
| K9N54_RS09915 (K9N54_09865) | 2096572..2096664 | - | 93 | WP_080252029.1 | DUF3265 domain-containing protein | - |
| K9N54_RS09920 (K9N54_09870) | 2096984..2097091 | - | 108 | Protein_1927 | DUF3265 domain-containing protein | - |
| K9N54_RS09925 (K9N54_09875) | 2097188..2097430 | + | 243 | WP_023585842.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| K9N54_RS09930 (K9N54_09880) | 2097437..2097733 | + | 297 | WP_025793418.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| K9N54_RS09935 (K9N54_09885) | 2097902..2098264 | - | 363 | WP_029812447.1 | DUF2750 domain-containing protein | - |
| K9N54_RS09940 (K9N54_09890) | 2098398..2098805 | - | 408 | WP_025793419.1 | OsmC family protein | - |
| K9N54_RS09945 (K9N54_09895) | 2098964..2099302 | - | 339 | WP_025793420.1 | hypothetical protein | - |
| K9N54_RS09950 (K9N54_09900) | 2099323..2099415 | - | 93 | WP_080277531.1 | DUF3265 domain-containing protein | - |
| K9N54_RS09955 (K9N54_09905) | 2099430..2100176 | - | 747 | WP_025793421.1 | hypothetical protein | - |
| K9N54_RS09960 (K9N54_09910) | 2100212..2100301 | - | 90 | WP_072833192.1 | DUF3265 domain-containing protein | - |
| K9N54_RS09965 (K9N54_09915) | 2100331..2100807 | - | 477 | WP_025793422.1 | GNAT family N-acetyltransferase | - |
| K9N54_RS09970 (K9N54_09920) | 2100956..2101561 | - | 606 | WP_025543333.1 | BRCT domain-containing protein | - |
| K9N54_RS09975 (K9N54_09925) | 2102028..2102492 | - | 465 | WP_021485101.1 | DUF2846 domain-containing protein | - |
| K9N54_RS09985 | 2102654..2102722 | - | 69 | Protein_1939 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 2041179..2166543 | 125364 | |
| - | inside | Integron | - | - | 2090758..2165418 | 74660 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11305.96 Da Isoelectric Point: 9.3813
>T216308 WP_025793418.1 NZ_CP083361:2097437-2097733 [Vibrio parahaemolyticus]
MQKNKYKLSKLAQAHLIKIKNYTVNNFSEMQWRNYKDTLLTGFQMLADNPEVGRSCDDIYPNGFHFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL
MQKNKYKLSKLAQAHLIKIKNYTVNNFSEMQWRNYKDTLLTGFQMLADNPEVGRSCDDIYPNGFHFPVGKHTAYFTKEDG
FILVVAVLGQSQLPQNHL
Download Length: 297 bp
>T216308 NZ_CP113007:2465629-2465817 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8917.15 Da Isoelectric Point: 5.1006
>AT216308 WP_023585842.1 NZ_CP083361:2097188-2097430 [Vibrio parahaemolyticus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKADYLKHCFESAKKDLAQGNVVDGEDFLSAL
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKADYLKHCFESAKKDLAQGNVVDGEDFLSAL
Download Length: 243 bp
>AT216308 NZ_CP113007:2465340-2465600 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|